Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 24, 2025

Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly facilitating drug resistance. This article delves into emerging evidence linking exosomal lncRNAs to modulation resistance mechanisms cancers such ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these influence cancer cell survival, tumor microenvironment, chemotherapy efficacy. Additionally, review highlights potential therapeutic strategies targeting lncRNAs, proposing a new frontier overcoming By mapping interface resistance, this aims provide comprehensive understanding that could pave way innovative treatments improved patient outcomes female reproductive system cancers.

Language: Английский

Inter-Tissue Communication Mechanisms via Exosomes and Their Implications in Metabolic Diseases: Opportunities for Pharmacological Regulation

Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(1), P. 11 - 11

Published: March 6, 2025

Exosomes can transport regulatory biomolecules and are mediators of cellular signaling among metabolic tissues through endocrine mechanisms. Understanding the pathways processes underlying exosome-mediated inter-tissue communication is critical for elucidating molecular pathophysiology diseases such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disorders. Consequently, these mechanisms represent novel promising targets pharmacological regulation. We examined current knowledge regarding exosome physiology, interaction with target tissues, its role in tissue communication. also analyzed secretory profiles exosomes emphasizing their roles adipose tissue, liver, pancreas, skeletal muscle, small intestine, while discussing association diseases. In this sense, we propose exosomal pentad a framework highlighting inter-organ communication, where may regulate axis involving tissues. This model aligns ominous octet but emphasizes key regulators homeostasis potential therapeutic targets. The treatment emerges area pharmacologic exploration. For instance, strategies that prevent binding or expression cargo molecules miRNAs could be designed, using antagomiRs nanoparticles. Additionally, integrins like αvβ5 on membrane blocked monoclonal antibodies engineered targeted delivery molecules. Exosomes, regulation, hold to design precise molecular-level therapies minimizing systemic side effects.

Language: Английский

The Role of Long Non-Coding RNAs in Skeletal Muscle Pathophysiology: A Therapeutic Perspective

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Skeletal muscle, one of the largest organs in mammals, plays a pivotal role regulating body temperature, metabolism, and movement. It is versatile tissue that can undergo degeneration due to various factors such as disease, aging, or cancer, posing challenges cancer therapy. Conversely, it possesses remarkable ability regenerate. muscle composed both mononucleated cells, each with distinct functions during regeneration, multinucleated cells called myofibers. Recently, was demonstrated transcription mammalian pervasive, highlighting importance junk DNA. frequently codes for non-coding RNAs have gained increasing pathophysiology all tissues over past two decades. Following advent COVID-19 vaccines, RNA has assumed greater significance therapeutic applications. In this manuscript, we will explore impact long (lncRNAs) on regeneration investigate their potential

Language: Английский