Effects and mechanisms of APP and its cleavage product Aβ in the comorbidity of sarcopenia and Alzheimer’s disease DOI Creative Commons

Jiale Wu,

Jun Tang, Di Huang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 25, 2024

Sarcopenia and AD are both classic degenerative diseases, there is growing epidemiological evidence of their comorbidity with aging; however, the mechanisms underlying biology commonality have not yet been thoroughly investigated. APP a membrane protein that expressed in tissues only nervous system but also NMJ muscle. Deposition its proteolytic cleavage product, Aβ, has described as central component pathogenesis. Recent studies shown excessive accumulation aberrant expression muscle lead to pathological lesions, pathogenic mechanism by which products act skeletal less well understood. By summarizing analyzing literature concerning role, pathogenicity muscles, we aimed explore intrinsic myocerebral comorbidities provide new perspectives theoretical foundations for prevention treatment sarcopenia comorbidities.

Language: Английский

Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge DOI Creative Commons
Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 191 - 199

Published: Jan. 9, 2025

Language: Английский

Citations

1
Effects and mechanisms of APP and its cleavage product Aβ in the comorbidity of sarcopenia and Alzheimer’s disease DOI Creative Commons

Jiale Wu,

Jun Tang, Di Huang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 25, 2024

Sarcopenia and AD are both classic degenerative diseases, there is growing epidemiological evidence of their comorbidity with aging; however, the mechanisms underlying biology commonality have not yet been thoroughly investigated. APP a membrane protein that expressed in tissues only nervous system but also NMJ muscle. Deposition its proteolytic cleavage product, Aβ, has described as central component pathogenesis. Recent studies shown excessive accumulation aberrant expression muscle lead to pathological lesions, pathogenic mechanism by which products act skeletal less well understood. By summarizing analyzing literature concerning role, pathogenicity muscles, we aimed explore intrinsic myocerebral comorbidities provide new perspectives theoretical foundations for prevention treatment sarcopenia comorbidities.

Language: Английский

Citations

2