Unveiling Microbiota Profiles in Saliva and Pancreatic Tissues of Patients with Pancreatic Cancer
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(1), P. 119 - 119
Published: Jan. 9, 2025
The
pancreas,
previously
considered
a
sterile
organ,
has
recently
been
shown
to
harbor
its
own
microbiota
that
may
influence
tumor
biology
and
patient
outcomes.
Despite
increasing
interest
in
the
impact
of
microbiome
on
cancer,
relationship
between
pancreatic
tissue
oral
microbiomes
ductal
adenocarcinoma
(PDAC)
remains
limited.
In
this
study,
pancreas
patients
with
PDAC
were
compared
other
periampullary
cancers
(DC/AC)
healthy
control
group
using
16S
rRNA
gene
sequence
analysis.
results
showed
significant
reduction
microbial
diversity
saliva
cancer
controls,
while
exhibited
distinct
profile
their
tissues,
consisting
predominantly
Firmicutes,
Proteobacteria,
Actinobacter,
after
filtering
indoor
environment.
Notably,
presence
bacteria
such
as
Anoxybacillus,
Clostridium,
Bacillus
tissues
suggests
potential
translocation
from
cavity.
This
study
emphasizes
importance
understanding
role
body
fluid
proposing
dysbiosis
contribute
disease
progression.
Moreover,
suggest
environment
which
samples
are
collected
analyzed
is
also
important
analysis
studies.
Language: Английский
Microbiota Involvement in Acute and Chronic Pancreatitis
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
The
microbiota
plays
a
significant
role
in
the
development,
progression,
and
severity
of
both
acute
chronic
pancreatitis
through
mechanisms
involving
immune
modulation,
microbial
translocation,
gut
permeability.
intricate
relationship
between
reveals
distinct
which
forms
disease
manifest.
In
pancreatitis,
dysbiosis
leads
to
alterations
flora,
characterized
by
reduced
diversity
an
overrepresentation
pathogenic
bacteria.
This
is
associated
with
compromised
barrier
integrity
increased
bacterial
resulting
heightened
systemic
inflammation
mediated
lipopolysaccharides
Toll-like
receptor
activation.
contrast,
marked
persistent
imbalances
driven
ongoing
malnutrition,
further
exacerbating
state.
interactions
pancreatic
function
demonstrate
bidirectional
relationship,
where
contributes
injury
also
consequence
impaired
exocrine
function.
Overall,
advancing
our
knowledge
gut-pancreas
axis
will
enhance
understanding
pathology
inform
more
effective
treatment
strategies
for
individuals
affected
disorders.
Language: Английский