The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4276 - 4276

Published: Dec. 11, 2024

An increasing number of studies highlight the critical role both maternal and paternal nutrition body weight before conception in shaping offspring health. Traditionally, research has focused on factors, particularly utero exposures, as key determinants chronic disease development. However, emerging evidence underscores significant influence preconception health metabolic outcomes. While remains vital, with playing a pivotal fetal development, obesity poor are linked to increased risks disorders, including type 2 diabetes cardiovascular children. This narrative review aims synthesize recent findings effects health, emphasizing need for integrated early interventions. The literature search utilized PubMed, UNF One Search, Google Scholar, focusing RCTs; cohort, retrospective, animal studies; systematic reviews, excluding non-English non-peer-reviewed articles. this indicate that mediated by epigenetic changes sperm, such DNA methylation non-coding RNA, which gene expression offspring. Nutrient imbalances during parents can lead low birth risk, while deficiencies folic acid, iron, iodine, vitamin D developmental disorders. Additionally, elevates risk diseases Future should prioritize human explore parental nutrition, weight, lifestyle ensuring applicable across diverse populations. By addressing healthcare providers better reduce prevalence syndrome its associated future generations.

Language: Английский

Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 2, 2025

Urbanization has significantly transformed dietary habits worldwide, contributing to a globally increased burden of non-communicable diseases and altered gut microbiota landscape. However, it is often overlooked that the adverse effects these changes can be transmitted from mother offspring during early developmental stages, subsequently influencing predisposition various later in life. This review aims delineate detrimental maternal urban-lifestyle diet (urbanized diet) on early-life health assembly, provide mechanistic insights how urbanized mediates mother-to-offspring transfer bioactive substances both intrauterine extrauterine thus affects fetal neonatal development. Moreover, we also further propose framework for developing microbiome-targeted precision nutrition strategies specifically pregnant lactating women. The establishment such knowledge help develop proactive preventive measures beginning life, ultimately reducing long-term risk disease improving public outcomes.

Language: Английский

Kimchi-derived probiotic intervention improve metabolic health in a sex-specific manner in rat offspring affected by maternal diet and postnatal nutrition

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106867 - 106867

Published: May 6, 2025

Language: Английский