Pathogenetic association of inflammation and hemostasis markers in the blood of patients with injuries of large joints

TRAUMA, Journal Year: 2025, Volume and Issue: 26(1), P. 1 - 10

Published: March 7, 2025

Background. In patients with injuries of large joints, the activation inflammation causes risk thrombophilia. The prediction thrombotic complications and their prevention can improve quality treatment. purpose: to investigate data scientific medical literature on pathogenetic association between markers hemostasis in degenerative diseases post-traumatic joints. Materials methods. search for has been made PubMed database 10 years. Sixty works were selected. Results. A total 60 papers selected analysis. They recorded information about relationship mechanisms hypercoagulability trauma. specified are given this work. Conclusions. orthopedics traumatology, considerable attention is paid surgical treatment trauma, particular, Individuals trauma or surgery joints have a correlation biochemical common clinical inflammation, metabolism glycoproteins, proteoglycans collagen laboratory indicators hemostasis. case, significant damage formation vicious circle observed: decrease plasminogen content, which under action activators converted plasmin, trigger factor fibrinolytic system, that at same time activity acceleration dystrophic processes accumulation blood serum an excessive amount acute phase glycoproteins. addition, there increase plasma following coagulation markers: fibrinogen, soluble fibrin monomer complexes, D-dimers, inflammatory such as C-reactive protein, haptoglobin. From this, it follows postoperative requires timely monitoring markers, well measures prevent thrombophilia, including prehospital stage.

Language: Английский

Cytokine storm polymorphisms in nonvaccinated COVID-19 patients

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Cytokines and chemokines are essential for establishing an appropriate immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Variations in the genes encoding cytokines strongly influence pathogenic challenges disease outcomes. This study was carried out determine associations of polymorphisms TNF -α , IL-6 IL-8, IL-10 CCL5 with COVID-19 severity. A total 627 unvaccinated patients were classified according WHO We evaluated levels IFN-α, IFN-γ, TNF-α, IL-1R, IL-6, IL-7, IL-10, CCL2, CCL3, CXCL8, CXCL10 GCSF serum compared among severity groups stratified by polymorphism alleles. revealed a significant increase IL-2, CCL-2 dead group. However, higher moderate group than mild Logistic regression analysis that five associated increased risk COVID-19: (rs1800610) allele (OR=1.50; 95% CI: 1.01–2.24); (rs1800796) C (OR=1.64; 1.05–2.57); (rs1800871) T (OR=1.94; 1.24–3.04) (rs1800872) (OR=1.87; 1.21–2.89); (rs3817656) G (OR= 1.64; 1.02–2.65)). The (rs1800871 rs1800872) (rs1800796 rs18049563) gene also Increases carriers rs1049953. In contrast, not any SNPs.

Language: Английский

Serum sST2: key biomarkers in COVID-19 patients with implications for coronary artery disease

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 7, 2025

As the coronavirus disease-2019 (COVID-19) pandemic persists, post-COVID-19 syndrome (PS), characterized by symptoms like chest pain, fatigue, and palpitations, is becoming a significant medical social issue. COVID-19 patients with existing coronary artery disease (CAD) may face higher risks of complications. It crucial to assess if PS also have CAD, though data limited. We studied 75 68 non-COVID-19 admitted our hospital between 2022/12/20 2023/01/20. Demographic, laboratory, clinical were collected upon admission. The Gensini score (GS) was used atherosclerosis severity. Patients categorized GS traits identify potential independent linked CAD had levels serum soluble growth stimulation expression gene 2 protein (sST2), myeloperoxidase, ALT, AST, PT, B-type natriuretic peptide (BNP), hypersensitive troponin-I (hs-cTnI), along longer stays, more ICU admissions, increased heart failure ACS morbidity compared those without CAD. Univariate multivariate analysis identified sST2 as an risk factor for coexisting (odds ratio 1.122). positively correlated angiography (r = 0.474, p < 0.001) in significantly cases ≥ 32, regardless status (p specifically 0.006). ROC showed predicted admission, stay duration, HF similarly GS. Admission should be considered CAD-like treatment planning could serve prognostic biomarker co-existing practice.

Language: Английский