Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 138 - 138

Published: Jan. 16, 2025

Origanum majorana L., also known as sweet marjoram, is a plant with multiple uses, both in the culinary field and traditional medicine, because of its major antioxidant, anti-inflammatory, antimicrobial, digestive properties. In this research, we focused on effects O. essential oil (OmEO, at concentrations 25, 150, 300 μL/L), evaluating chemical structure well impact cognitive performance oxidative stress, naive zebrafish (Danio rerio), scopolamine-induced amnesic model (SCOP, 100 μM). The fish behavior was analyzed novel tank-diving test (NTT), Y-maze test, object recognition (NOR) test. We investigated acetylcholinesterase (AChE) activity brain's stress status. parallel, performed silico predictions (research conducted using computational models) pharmacokinetic properties main compounds identified OmEO, platforms such SwissADME, pKCSM, ADMETlab 2.0, ProTox-II. results revealed that were trans-sabinene hydrate (36.11%), terpinen-4-ol (17.97%), linalyl acetate (9.18%), caryophyllene oxide (8.25%), α-terpineol (6.17%). OmEO can enhance memory through AChE inhibition, reduce SCOP-induced anxiety by increasing time spent top zone NTT, significantly markers. These findings underscore potential to improve impairment associated disorders, including Alzheimer's disease (AD).

Language: Английский

Mitochondrial Dysfunction in Alzheimer’s Disease

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102713 - 102713

Published: Feb. 1, 2025

Language: Английский