Natural compounds: new therapeutic approach for inhibition of Streptococcus mutans and dental caries DOI Creative Commons

Milad Kashi,

Mahdieh Varseh,

Yasaman Hariri

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Streptococcus mutans is recognized as one of the leading causes dental caries, and biofilm formation by this bacterium plays a key role in plaque development caries progression. Given increasing resistance bacteria to antibiotics adverse effects some synthetic antimicrobials, search for natural alternatives has received attention. The recently published studies have demonstrated that compounds (NCs) such curcumin, cinnamaldehyde, eugenol, thymol, carvacrol, epigallocatechin gallate, farnesol, catechin, inulin, menthol, apigenin, myricetin, oleanolic acid, resveratrol, notable antimicrobial properties can effectively inhibit growth mutans. NCs disrupt bacterial membrane integrity, cell death, possess capability acid production, which factor development. also interfere with adhesion surfaces, including teeth. attachment inhibition achieved decreasing expression factors gtfs, ftf, fruA, gbpB. metabolism, formation, disperse existing biofilm, quorum sensing two-component signal transduction systems. Moreover, novel drug delivery platforms were used enhance bioavailability stability NCs. Studies indicated exhibit significant efficacy combination therapies. Notably, curcumin shown promising results photodynamic therapy against S. current review article analyzes mechanisms action various investigates their potential alternative or complementary therapeutic options managing caries.

Language: Английский

Natural compounds: new therapeutic approach for inhibition of Streptococcus mutans and dental caries DOI Creative Commons

Milad Kashi,

Mahdieh Varseh,

Yasaman Hariri

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Streptococcus mutans is recognized as one of the leading causes dental caries, and biofilm formation by this bacterium plays a key role in plaque development caries progression. Given increasing resistance bacteria to antibiotics adverse effects some synthetic antimicrobials, search for natural alternatives has received attention. The recently published studies have demonstrated that compounds (NCs) such curcumin, cinnamaldehyde, eugenol, thymol, carvacrol, epigallocatechin gallate, farnesol, catechin, inulin, menthol, apigenin, myricetin, oleanolic acid, resveratrol, notable antimicrobial properties can effectively inhibit growth mutans. NCs disrupt bacterial membrane integrity, cell death, possess capability acid production, which factor development. also interfere with adhesion surfaces, including teeth. attachment inhibition achieved decreasing expression factors gtfs, ftf, fruA, gbpB. metabolism, formation, disperse existing biofilm, quorum sensing two-component signal transduction systems. Moreover, novel drug delivery platforms were used enhance bioavailability stability NCs. Studies indicated exhibit significant efficacy combination therapies. Notably, curcumin shown promising results photodynamic therapy against S. current review article analyzes mechanisms action various investigates their potential alternative or complementary therapeutic options managing caries.

Language: Английский

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