The Role of the Endocannabinoid System in Human Gametogenesis DOI Open Access
Nina Montik,

Daniele Crescenzi,

Carolina Marzocchini

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3996 - 3996

Published: April 23, 2025

The endocannabinoid system (ECS) is a complex endocrine network involved in maintaining body homeostasis. It comprises endocannabinoids, their receptors (CB1 and CB2), the enzymes transporters responsible for synthesis degradation. While ECS’s role nervous well established, its functions other organs peripheral tissues, including cardiovascular, gastrointestinal, reproductive systems, remain incompletely understood. With increasing use of marijuana, particularly among individuals age, concerns have emerged regarding potential impact on male female fertility. Phytocannabinoids (∆9tethrahydrocannabinol cannabidiol), as synthetic cannabimimetic drugs, interact with ECS, influencing sperm oocyte physiology outcomes. Recent research has identified ECS-related biomarkers applications infertility diagnosis, assessing fertility greater precision. Furthermore, emerging evidence suggests that ECS signaling pathways are epigenetic modifications, which may influence health maintenance, disease susceptibility, transgenerational inheritance patterns. These findings highlight therapeutic modulation disorders broader medical applications. This narrative review aims to elucidate human reproduction, particular focus endocannabinoids gametogenesis. current underscores critical fertility, further investigations needed fully underlying mechanisms implications interventions.

Language: Английский

Sex-specific alterations in emotional behavior and neurotransmitter systems in LPA1 receptor-deficient mice DOI
Laura Sánchez‐Marín,

Violeta Jiménez-Castilla,

María Flores-López

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110325 - 110325

Published: Jan. 1, 2025

Language: Английский

Citations

0
Associations of cachexia and frailty with amyotrophic lateral sclerosis DOI Creative Commons
Tracy L. Peters, Weihong Qiu, Haomin Yang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 5, 2025

Abstract In the present study, we investigated associations of cachexia (loss muscle, weight and fat) frailty muscle) status with risk developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. prospective extracted from UK Biobank cohort to study conditions (as determined via international classification disease-10 codes) sclerosis. There was a greater sclerosis among individuals after adjusting for age, sex, income (pounds), body mass index, centers smoking status. Among status: grip strength < 21 kg, slow walking speed, exhaustion (more than half days or nearly every day) increase We believe that studying can be help define treat

Language: Английский

Citations

0
Improved recognition memory and reduced inflammation following β-caryophyllene treatment in the Wistar-Kyoto rodent model of treatment-resistant depression DOI Creative Commons
Helen Clunas, Samara Walpole,

Ilijana Babic

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111312 - 111312

Published: March 1, 2025

Persistent low mood, anxiety and cognitive deficits are common symptoms of depression highly efficacious treatments that address including dysfunction still required. β-caryophyllene (BCP) is a terpene with anti-inflammatory pro-cognitive properties; however, its efficacy on cognition in remains unclear. This study aimed to investigate acute chronic BCP treatment effects cognitive, depressive- anxiety-like behaviours, inflammation male female Wistar-Kyoto (WKY) rats, rodent model treatment-resistant depression. Rats were administered either (50 mg/kg) or vehicle (control). Open field (OFT), social interaction, sucrose preference, novel object recognition (NOR) elevated plus maze (EPM) tests conducted after (1 h) (2 weeks) treatment. Peripheral plasma inflammatory cytokine levels examined. acutely increased locomotor activity the OFT but did not improve whereas prevented latency first interaction females (not males). preference prevent behaviours EPM. significantly discrimination NOR test WKY rats reduced shows for time improved memory exerted properties depressive-like behaviours. anhedonia sex. These findings demonstrate worthy further investigation.

Language: Английский

Citations

0
Acute cannabis intoxication among the paediatric population DOI Creative Commons
Ginevra Malta, Giuseppe Albano, Gianluca Lavanco

et al.

Frontiers in Toxicology, Journal Year: 2025, Volume and Issue: 7

Published: April 14, 2025

This narrative review synthesizes the toxicological, clinical and medico-legal aspects of paediatric cannabis intoxication. By providing a comprehensive overview, it aims to inform future research, guide policymaking, enhance toxicological practice in addressing this growing public health concern. The pharmacokinetics cannabinoid ingestion children are significantly influenced by immaturity their gastrointestinal tract metabolic enzyme systems, resulting altered oral bioavailability. Clinical data indicate that Δ9-tetrahydrocannabinol (THC)-related effects paediatricpaediatric patients typically emerge within 2 hours ingestion, with more severe symptoms developing 4 hours. endocannabinoid system (ECS) undergoes significant developmental changes, marked differences receptor expression distribution across fetal, neonatal, adult brains. During neurodevelopment, CB1 receptors exhibit unique patterns, including transient localization brainstem regions critical for neurovegetative functions. These dynamics likely explain children’s heightened sensitivity THC’s neurological effects, often outcomes compared adults. reliable detection cannabinoids involves integrating screening methods confirmatory analytical techniques. Urine immunoassay testing is widely considered an helpful toolto assess previous exposure, becoming positive 3–4 h ingestion. However, method prone false positives. Plasma THC concentration, when measured close event, offers valuable insights into quantity ingested correlation between exposure impairment window. Hair analysis, while useful distinguishing acute chronic use, susceptible various biases. rising incidence intoxication underscores urgent need targeted interventions stricter regulatory frameworks. Preventive measures such as child-resistant packaging, education campaigns, use during pregnancy essential mitigate risks. Clinicians should consider differential diagnosis presenting unexplained neurological, immune, or symptoms.

Language: Английский

Citations

0
The Role of the Endocannabinoid System in Human Gametogenesis DOI Open Access
Nina Montik,

Daniele Crescenzi,

Carolina Marzocchini

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3996 - 3996

Published: April 23, 2025

The endocannabinoid system (ECS) is a complex endocrine network involved in maintaining body homeostasis. It comprises endocannabinoids, their receptors (CB1 and CB2), the enzymes transporters responsible for synthesis degradation. While ECS’s role nervous well established, its functions other organs peripheral tissues, including cardiovascular, gastrointestinal, reproductive systems, remain incompletely understood. With increasing use of marijuana, particularly among individuals age, concerns have emerged regarding potential impact on male female fertility. Phytocannabinoids (∆9tethrahydrocannabinol cannabidiol), as synthetic cannabimimetic drugs, interact with ECS, influencing sperm oocyte physiology outcomes. Recent research has identified ECS-related biomarkers applications infertility diagnosis, assessing fertility greater precision. Furthermore, emerging evidence suggests that ECS signaling pathways are epigenetic modifications, which may influence health maintenance, disease susceptibility, transgenerational inheritance patterns. These findings highlight therapeutic modulation disorders broader medical applications. This narrative review aims to elucidate human reproduction, particular focus endocannabinoids gametogenesis. current underscores critical fertility, further investigations needed fully underlying mechanisms implications interventions.

Language: Английский

Citations

0