Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma DOI Creative Commons

Guodan Zeng,

Xinyu Liu, H. Lv

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 61 - 61

Published: Jan. 13, 2025

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.

Language: Английский

Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma DOI Creative Commons

Guodan Zeng,

Xinyu Liu, H. Lv

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 61 - 61

Published: Jan. 13, 2025

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.

Language: Английский

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