Parkinson’s Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART DOI Open Access
Dušica Kovačević, Gordana Velikić, D Marić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3348 - 3348

Published: April 3, 2025

Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA's typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson's spectrum mechanisms to explore hypothetical for how pregnancy-induced physiological changes might influence progression. Pregnancy-induced hormonal fluctuations, including elevated estrogen progesterone levels, may modulate α-synuclein aggregation neuroinflammatory pathways. Immune adaptations, such as fetal microchimerism Th2-biased immune profiles, introduce additional complexities, particularly donor embryo complex microchimerism. Metabolic demands oxidative stress further intersect with these mechanisms, potentially accelerating disease We analyze existing literature theoretical models, emphasizing need interdisciplinary research. Clinical implications are discussed propose evidence-based strategies optimizing maternal-fetal outcomes. This paper identifies critical knowledge gaps proposes avenues future investigation optimize outcomes unique underexplored intersection.

Language: Английский

AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis DOI Open Access
Sandra Maria Barbalho, Lucas Fornari Laurindo,

Bárbara de Oliveira Zanuso

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 484 - 484

Published: Jan. 8, 2025

Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.

Language: Английский

Citations

1
Metformin’s Effects on Cognitive Function from a Biovariance Perspective: A Narrative Review DOI Open Access

Dimitrie Chele,

Carmen Adella Sîrbu,

Marian Mitrică

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1783 - 1783

Published: Feb. 19, 2025

This study examines the effects of metformin on brain functions focusing variability results reported in literature. While some studies suggest that may have neuroprotective diabetic patients, others report an insignificant impact cognitive function, or even a negative effect. We propose this inconsistency be due to intrinsic cellular-level among individuals, which we term "biovariance". Biovariance persists demographically homogeneous samples complex and stochastic biological processes. Additionally, metabolic actions metformin, including its influence neuroenergetics neuronal survival, produce different depending individual characteristics.

Language: Английский

Citations

1
Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models DOI Creative Commons
Edna Grünblatt, Cristine Marie Yde Ohki,

G Angelika Schmitt-Böhrer

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Insulin resistance may hold the key to Alzheimer's disease DOI

George Winter

British Journal of Nursing, Journal Year: 2025, Volume and Issue: 34(4), P. 202 - 206

Published: Feb. 19, 2025

Language: Английский

Citations

0
Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review DOI Open Access
Vicente Javier Clemente‐Suárez, Laura Redondo-Flórez, Alexandra Martín-Rodríguez

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 884 - 884

Published: Feb. 28, 2025

The global shift towards vegan and vegetarian diets has garnered attention for their ethical, environmental, potential health benefits. These are often rich in phytonutrients antioxidants, which have been associated with lower levels of inflammatory markers, such as C-reactive protein (CRP) interleukin-6 (IL-6), suggesting a protective effect against systemic inflammation oxidative stress. However, despite these benefits, concerns remain regarding impact on neurological due to the possible deficiencies critical nutrients vitamin B12, DHA, EPA, iron. This review critically evaluates influence dietary patterns outcomes, emphasizing nutritional composition, deficiencies, interplay A systematic literature published between 2010 2023 was conducted, focusing studies that explore relationship health. Key omega-3 fatty acids, iron, zinc were analyzed alongside antinutritional factors effects nervous system. Evidence suggests diets, when well planned, can be (IL-6). findings indicate role reducing stress, both linked neurodegenerative diseases. iron consistently an increased risk cognitive decline, mood disturbances, disorders. Additionally, presence like phytates oxalates may further impair nutrient absorption, necessitating careful planning supplementation. While plant-based provide anti-inflammatory antioxidant implications depend adequacy. Proper planning, supplementation, food preparation techniques essential mitigate risks enhance Further research is needed long-term outcomes optimize strategies.

Language: Английский

Citations

0
Potential Mechanism and Efficacy Evaluation of Transcranial Focused Ultrasound Therapy for Alzheimer's Disease DOI
Wei Qin,

Jiayi He,

Yi Zhou

et al.

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110428 - 110428

Published: March 1, 2025

Language: Английский

Citations

0
Evaluating the Link Between Cardiovascular Risk and Alzheimer’s Disease: A Comprehensive Case-Control Study in Castilla y León, Spain DOI Creative Commons
Laura Bello-Corral, Jesús Seco‐Calvo,

Marta Celorrio San Miguel

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 3409 - 3409

Published: March 20, 2025

Alzheimer’s disease (AD) represents a growing public health challenge due to its increasing prevalence, projected reach 150 million cases by 2050. Characterised neuropathological changes such as the accumulation of beta-amyloid peptide and hyperphosphorylated Tau protein, is related genetic environmental factors. The main objective this research has been analyse possible relationship between some cardiovascular factors AD. This analytical observational case-control study carried out in Castilla y León (Spain), comprised total 511 individuals 60 90 years age, whom 260 had diagnosis AD rest were healthy individuals. results showed that group with predominantly women, widowed primary education, who higher prevalence family history disease. It was also observed hypertension, cardiac pathology diabetes mellitus three risk significant increased differences patients compared control Although precise mechanisms require further research, these underline importance addressing complex interactions prevention

Language: Английский

Citations

0
Post-traumatic stress disorder, metabolic syndrome, diabetic distress, and vitamin B1/benfotiamine DOI Open Access
Victoria Serhiyenko, O.М. Chemerys, V.І. Pankiv

et al.

INTERNATIONAL NEUROLOGICAL JOURNAL, Journal Year: 2025, Volume and Issue: 21(1), P. 96 - 107

Published: March 20, 2025

A person with post-traumatic stress disorder (PTSD) is more likely to develop metabolic syndrome (MetS), depression, and diabetic distress. It also raises the risk of cardiometabolic neurodegenerative diseases (NDD). At same time, type 2 diabetes mellitus MetS can cause development core neurosis-like psychiatric symptoms characteristic PTSD. Chronic associated cardiovascular diseases, diabetes, NDD. More people think that mitochondrial dysfunction, peripheral/central chronic low-grade inflammation (CLGI), oxidative are main causes these diseases. Pathophysiological processes link them together. To make things better for patients, interventions aim control CLGI may be better, following ideas precision medicine. Deficiency certain biofactors, in particular, vitamin B1, an increased MetS, Targeted effects on CLGI, stress, metabolism disorders suggest use antioxidants, particularly B1/benfotiamine (BFT), have a positive effect not only course comorbid but manifestations Exogenous or BFT, corrects thiamine status disorders. BFT exhibits potent animal models NDD, stress-induced anxiety, aggression, depression. Thus, considered potentially safe cost-effective drug treatment many central nervous system Despite its aspects, therapeutic potential remains limited, as beneficial require high doses over long period time. Dibenzoylthiamine, lipophilic form has been shown anti-inflammatory antioxidant at much lower than both vitro vivo. However, preclinical clinical studies needed sure viability dibenzoylthiamine. This review pays extra attention analysis features biological role mechanism action, especially impact glucose function, state neuroinflammation, how dibenzoylthiamine protect neurons. We conducted search Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. The keywords used were “thiamine”, “benfotiamine”, “dibenzoylthiamine”, “post-traumatic disorder”, “metabolic syndrome”, “diabetic distress”, “diabetes mellitus”. manual bibliography publications pinpoint research results eluded online search.

Language: Английский

Citations

0
Overview of Metformin and Neurodegeneration: A Comprehensive Review DOI Creative Commons
Weronika Kruczkowska, Julia Gałęziewska, Paulina Buczek

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 486 - 486

Published: March 28, 2025

This comprehensive review examines the therapeutic potential of metformin, a well-established diabetes medication, in treating neurodegenerative disorders. Originally used as first-line treatment for type 2 diabetes, recent studies have begun investigating metformin’s effects beyond metabolic disorders, particularly its neuroprotective capabilities against conditions like Parkinson’s disease, Alzheimer’s Huntington’s and multiple sclerosis. Key findings demonstrate that operate through pathways: AMPK activation enhancing cellular energy metabolism autophagy; upregulation antioxidant defenses; suppression inflammation; inhibition protein aggregation; improvement mitochondrial function. These mechanisms collectively address common pathological features neurodegeneration neuroinflammation, including oxidative stress, accumulation, dysfunction. Clinical preclinical evidence supporting association with improved cognitive performance, reduced risk dementia, modulation hallmarks diseases is critically evaluated. While metformin shows promise agent, this emphasizes need further investigation to fully understand optimal applications diseases.

Language: Английский

Citations

0
Exercise‐induced signalling in alleviating neuronal insulin resistance DOI

Ishitha Reddy,

Chinmoy Sankar Dey

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Exercise contributes to a multitude of positive changes within the body and brain with regard glucose homeostasis, insulin sensitivity, synaptic plasticity, neuroprotection neurogenesis, among other effects. It provides non-pharmaceutical alternative for addressing metabolic disorders in individuals type 2 diabetes, who also face an increased risk developing Alzheimer's disease. A number molecules are evoked upon exercise circulate through bloodstream, transmitting wide-reaching advantages exercise. The ensuing cross-talk has been shown improve conditions associated vast signalling network mediated by is currently being studied extensively its implications improving neuronal resistance, especially as bypass mechanism, major interest. Taking into account sirtuin 1/peroxisome proliferator-activated receptor γ co-activator 1-α, AMP-activated protein kinase, phosphoinositide 3-kinase/AKT, phospholipase C-γ brain-derived neurotrophic factor/tropomyosin kinase B many pathways cross-interactions involved, researching molecular characteristics mechanisms which it compensates hampered crucial future research.

Language: Английский

Citations

0