Parkinson’s Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART DOI Open Access
Dušica Kovačević, Gordana Velikić, D Marić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3348 - 3348

Published: April 3, 2025

Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA's typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson's spectrum mechanisms to explore hypothetical for how pregnancy-induced physiological changes might influence progression. Pregnancy-induced hormonal fluctuations, including elevated estrogen progesterone levels, may modulate α-synuclein aggregation neuroinflammatory pathways. Immune adaptations, such as fetal microchimerism Th2-biased immune profiles, introduce additional complexities, particularly donor embryo complex microchimerism. Metabolic demands oxidative stress further intersect with these mechanisms, potentially accelerating disease We analyze existing literature theoretical models, emphasizing need interdisciplinary research. Clinical implications are discussed propose evidence-based strategies optimizing maternal-fetal outcomes. This paper identifies critical knowledge gaps proposes avenues future investigation optimize outcomes unique underexplored intersection.

Language: Английский

Parkinson’s Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART DOI Open Access
Dušica Kovačević, Gordana Velikić, D Marić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3348 - 3348

Published: April 3, 2025

Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA's typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson's spectrum mechanisms to explore hypothetical for how pregnancy-induced physiological changes might influence progression. Pregnancy-induced hormonal fluctuations, including elevated estrogen progesterone levels, may modulate α-synuclein aggregation neuroinflammatory pathways. Immune adaptations, such as fetal microchimerism Th2-biased immune profiles, introduce additional complexities, particularly donor embryo complex microchimerism. Metabolic demands oxidative stress further intersect with these mechanisms, potentially accelerating disease We analyze existing literature theoretical models, emphasizing need interdisciplinary research. Clinical implications are discussed propose evidence-based strategies optimizing maternal-fetal outcomes. This paper identifies critical knowledge gaps proposes avenues future investigation optimize outcomes unique underexplored intersection.

Language: Английский

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