
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(2)
Published: March 1, 2025
ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.
Language: Английский