Emodin Improves Juvenile Largemouth Bass (Micropterus salmoides) Liver Health Through Nrf2/NF-κB Pathway and Fat Metabolism: Growth Performance, Immune Response and Resistance Against Aeromonas veronii Infection DOI Creative Commons
Zhenxin Zhao, Fei Zhao,

Tianxun Luo

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(2), P. 178 - 178

Published: Jan. 10, 2025

The experiment was aimed at examining the influence of adding emodin to feeds on growth performance, liver immunity, and resistance against Aeromonas veronii infection among juvenile largemouth basses other potential mechanisms. A total 540 fish (45 ± 0.3 g) were randomly divided into 6 diets, including EM-0, EM-250, EM-500, EM-1000, EM-2000, EM-4000 in which 0, 250, 500, 1000, 2000, 4000 mg kg-1 added. Following a 60-day feeding test, it demonstrated that feed conversion ratio (FCR) juveniles within EM-500 EM-1000 groups remarkably exceeded EM-0 group. Subsequently, unlike those group, group showed heightened hepatocyte count, induced hepatic lipolysis-associated expression peroxisome proliferators-activated receptor α (PPARα) acyl-coenzyme an oxidase (ACO), reduced triglyceride (TG) levels. Additionally, could up-regulate expressions nuclear factor erythroid 2-associated 2 (Nrf2) heme oxygenase-1 (HO-1) livers compared with controls boost antioxidant enzymes activities superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), along lower content reactive oxygen species (ROS) malondialdehyde (MDA). Meanwhile, increased anti-inflammatory cytokines interleukin-10 (IL-10) while suppressing interleukin-8 (IL-8) pro-inflammatory by contrast controls. In end, bass comparatively highest survival rate, whereas EM-2000 exhibited little higher mortality than To sum up, our study exposed supplementing 1000 diet enhance status unspecific immunity reinforce protective effect disease resistance, resulting improving performance bass.

Language: Английский

Emodin Improves Juvenile Largemouth Bass (Micropterus salmoides) Liver Health Through Nrf2/NF-κB Pathway and Fat Metabolism: Growth Performance, Immune Response and Resistance Against Aeromonas veronii Infection DOI Creative Commons
Zhenxin Zhao, Fei Zhao,

Tianxun Luo

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(2), P. 178 - 178

Published: Jan. 10, 2025

The experiment was aimed at examining the influence of adding emodin to feeds on growth performance, liver immunity, and resistance against Aeromonas veronii infection among juvenile largemouth basses other potential mechanisms. A total 540 fish (45 ± 0.3 g) were randomly divided into 6 diets, including EM-0, EM-250, EM-500, EM-1000, EM-2000, EM-4000 in which 0, 250, 500, 1000, 2000, 4000 mg kg-1 added. Following a 60-day feeding test, it demonstrated that feed conversion ratio (FCR) juveniles within EM-500 EM-1000 groups remarkably exceeded EM-0 group. Subsequently, unlike those group, group showed heightened hepatocyte count, induced hepatic lipolysis-associated expression peroxisome proliferators-activated receptor α (PPARα) acyl-coenzyme an oxidase (ACO), reduced triglyceride (TG) levels. Additionally, could up-regulate expressions nuclear factor erythroid 2-associated 2 (Nrf2) heme oxygenase-1 (HO-1) livers compared with controls boost antioxidant enzymes activities superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), along lower content reactive oxygen species (ROS) malondialdehyde (MDA). Meanwhile, increased anti-inflammatory cytokines interleukin-10 (IL-10) while suppressing interleukin-8 (IL-8) pro-inflammatory by contrast controls. In end, bass comparatively highest survival rate, whereas EM-2000 exhibited little higher mortality than To sum up, our study exposed supplementing 1000 diet enhance status unspecific immunity reinforce protective effect disease resistance, resulting improving performance bass.

Language: Английский

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