Age as a limiting factor for effectiveness of photostimulation of brain drainage and cognitive functions DOI Creative Commons

Terskov Andrey,

Shirokov Alexander,

Blokhina Inna

et al.

Frontiers of Optoelectronics, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 31, 2025

Abstract The progressive number of old adults with cognitive impairment worldwide and the lack effective pharmacologic therapies require development non-pharmacologic strategies. photobiomodulation (PBM) is a promising method in prevention early or mild age-related impairments. However, it remains unclear efficacy PBM for patients significant dysfunction. In our study on male mice, we show gradual increase brain amyloid beta (Aβ) levels decrease drainage age, which, however, associated decline function only (24 months age) mice but not middle-aged (12 young (3 month animals. These features are accompanied by hyperplasia meningeal lymphatic vessels (MLVs) underlying drainage. improves training exercises Aβ clearance while animals sensitive to PBM. results clearly demonstrate that effects correlated age-mediated changes MLV network may be if preserved. findings expand fundamental knowledge about age differences effectiveness improvement functions as well mechanisms responsible sensitivity therapeutic effects. Graphical

Language: Английский

Age as a limiting factor for effectiveness of photostimulation of brain drainage and cognitive functions DOI Creative Commons

Terskov Andrey,

Shirokov Alexander,

Blokhina Inna

et al.

Frontiers of Optoelectronics, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 31, 2025

Abstract The progressive number of old adults with cognitive impairment worldwide and the lack effective pharmacologic therapies require development non-pharmacologic strategies. photobiomodulation (PBM) is a promising method in prevention early or mild age-related impairments. However, it remains unclear efficacy PBM for patients significant dysfunction. In our study on male mice, we show gradual increase brain amyloid beta (Aβ) levels decrease drainage age, which, however, associated decline function only (24 months age) mice but not middle-aged (12 young (3 month animals. These features are accompanied by hyperplasia meningeal lymphatic vessels (MLVs) underlying drainage. improves training exercises Aβ clearance while animals sensitive to PBM. results clearly demonstrate that effects correlated age-mediated changes MLV network may be if preserved. findings expand fundamental knowledge about age differences effectiveness improvement functions as well mechanisms responsible sensitivity therapeutic effects. Graphical

Language: Английский

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