Antimicrobial Potential of Cannabinoids: A Scoping Review of the Past 5 Years

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 325 - 325

Published: Feb. 2, 2025

In the scenario of fighting bacterial resistance to antibiotics, natural products have been extensively investigated for their potential antibacterial activities. Among these, cannabinoids—bioactive compounds derived from cannabis—have garnered attention diverse biological activities, including anxiolytic, anti-inflammatory, analgesic, antioxidant, and neuroprotective properties. Emerging evidence suggests that cannabinoids may also possess significant antimicrobial properties, with applications in enhancing efficacy conventional agents. Therefore, this review examines past five years on properties cannabinoids, focusing underlying mechanisms such as microbial membrane disruption, immune response modulation, interference virulence factors. addition, synergistic potential, when used alongside standard therapies, underscores promise a novel strategy address drug resistance, although further research clinical trials are needed validate therapeutic use. Overall, offer promising avenue development innovative treatments combat drug-resistant infections reduce reliance traditional

Language: Английский

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New Cannabinoids and Chlorin-Type Metabolites from the Flowers of Cannabis sativa L.: A Study on Their Neuroblastoma Activity

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 521 - 521

Published: April 3, 2025

Background/Objectives: Cannabis sativa has been utilized for medical purposes thousands of years. It continues to be recognized as a plant with an extensive variety medicinal and nutraceutical uses today. In this study, chemical investigation the flowers C. isolated by using chromatographic techniques led isolation eleven compounds. These purified compounds were evaluated antitumor activity against SK-N-SH neuroblastoma cells. Methods: The techniques. Their structures identified examination spectroscopic methods, including 1D (1H, 13C, DEPT) 2D (COSY, HSQC, HMBC, NOESY) nuclear magnetic resonance (NMR) spectra mass spectrum, together comparison those reported previously in literature. evaluation toxicity on cells was performed MTT method. Results: Eleven from sativa, two new compounds, namely cannabielsoxa (1), 132-hydroxypheophorbide c ethyl ester (2), six known cannabinoids (6–11), first chlorin-type compounds: pyropheophorbide A (3), b (4), ligulariaphytin (5) plant. results also demonstrated that cannabinoid had stronger inhibitory effects than Conclusions: biological activities showed 4–10 could considered potential neuroblastomas. This is highlighted docking analysis. Additionally, study suggest these have developed into antineuroblastoma products.

Language: Английский

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Changes in Growth and Secondary Metabolite Production in Cannabis Sativa L. in Response to Simultaneous Treatment with Plasma Activated water, Melatonin and Nano-Zinc

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 4, 2025

Language: Английский

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Marketing Management and Policymaking for Medical Cannabis: Overcoming Barriers and Shaping Strategies

Cannabis, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Objective: Medical cannabis has emerged as a promising therapeutic option, but its market acceptance faces significant regulatory, societal, and scientific challenges. This study explores pharmaceutical business managers’ perspectives on marketing strategies, brand architecture, the value proposition of medical cannabis, aiming to identify approaches overcome these barriers guide policymaking. Method: Semi-structured interviews were conducted with 12 managers explore key challenges strategies. Results: Key themes included need for extensive research, targeted communication address stigma, effective tactics, long-term sustainability. Participants stressed importance rigorous, disease-specific research establish cannabis’ efficacy build trust healthcare providers patients. Societal stigma was identified major barrier, participants advocating strategies that distinguish from recreational use educate stakeholders. Marketing focused creating unique proposition, strong identity, adaptive meet diverse needs professionals, regulators, Additionally, phased entry beginning pilot programs in regions progressive regulatory environments, recommended pave way broader expansion. Conclusions: offers valuable insights into management policymaking necessary integrating market. By addressing uncertainties, societal gaps, companies can unlock full potential credible product. These findings lay groundwork future promote sustainable growth emerging

Language: Английский

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Assessing the Market Readiness for Medical Cannabis in Greece: A Qualitative Study of Patient Perspectives

Medicines, Journal Year: 2025, Volume and Issue: 12(2), P. 12 - 12

Published: May 9, 2025

Background: The introduction of medical cannabis in Greece marks a shift healthcare policy, yet patient attitudes remain underexplored. Methods: This qualitative study examines the market readiness for through semi-structured interviews with 24 participants-12 users cannabidiol (CBD)-based formulations and 12 cannabis-naive individuals. Results: CBD-experienced patients generally perceive cannabis-based treatments as beneficial managing musculoskeletal pain, migraines, anxiety, stress sleep disturbances, despite concerns over product quality, cost limited guidance. Medical participants express skepticism due to stigma perceived insufficient evidence but acknowledge potential therapeutic value within regulated framework. highlights need better education, physician training clear regulatory guidelines support responsible entry. Conclusions: These findings offer important insights policymakers, providers pharmaceutical industry, emphasizing structured, evidence-based approach integration Greece. Further research is needed assess long-term experiences evolving impact changes on dynamics.

Language: Английский

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Biological Activities in Supercritical CO₂-Extracted Cannabis: Comparison with Conventional Extraction Method

The Journal of Supercritical Fluids, Journal Year: 2025, Volume and Issue: unknown, P. 106606 - 106606

Published: March 1, 2025

Language: Английский

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Healthcare Professionals’ Perceptions About Medical Cannabis in Greece: A Qualitative Study

Journal of Market Access & Health Policy, Journal Year: 2025, Volume and Issue: 13(2), P. 13 - 13

Published: April 2, 2025

Background: Medical cannabis continues to generate interest as a potential therapeutic option, yet its acceptance in clinical practice faces challenges, including regulatory barriers, social stigma, and gaps scientific evidence. Methods: This study explores the perspectives of Greek medical doctors pharmacists on cannabis—key stakeholders application—through semi-structured interviews with 12 participants from each profession. Results: expressed range views cannabis, many acknowledging while emphasizing need for rigorous, disease-specific research. highlighted lack consistent trials, concerns about drug interactions, fine line between use misuse. Pharmacists echoed these concerns, citing inconsistencies standardized dosing. Both groups agreed that stigma misinformation hinder adoption, advocating targeted education transparent research communication. Participants indicated barriers also pose calls harmonized policies phased market entry approaches. Effective communication strategies, digital outreach clear messaging, were suggested differentiate recreational improve trust among healthcare providers patients. urgent collaboration policymakers, researchers, professionals establish credible option. Conclusion: The insights gained provide actionable recommendations bridge existing emphasize responsible, evidence-based approach

Language: Английский

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Extraction of Cannabinoids from Cannabis Sativa L. Using High Pressure Solvents: An Overview of Different Processing Options

Published: Jan. 1, 2024

Language: Английский

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