Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition DOI Creative Commons

Elvira Marquez‐Paradas,

María Torrecillas-López,

Luna Barrera-Chamorro

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

The gut microbiota has co-evolved with its host, profoundly shaping the development and functioning of immune system. This co-evolution led to a dynamic relationship where microbial metabolites molecular signals influence maturation, tolerance, defense mechanisms, highlighting essential role in maintaining host health. Recently, bacterial extracellular vesicles (BEVs), membrane nanoparticles produced by bacteria, have emerged as important players balance potent modulators. These reflect characteristics contain nucleic acids, proteins, lipids, metabolites. They can regulate processes are involved neurological metabolic diseases due their ability distribute both locally systemically, affecting responses at levels. review provides comprehensive overview functional profile BEVs, detailing how nutrition influences production function these vesicles, antibiotics disrupt or alter composition, factors collectively impact immunity disease development. It also highlights potential BEVs precision nutritional strategies through dietary modulation, such incorporating prebiotic fibers enhance beneficial BEV production, reducing intake processed foods that may promote harmful tailoring probiotic interventions specific communities vesicular outputs.

Language: Английский

Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition DOI Creative Commons

Elvira Marquez‐Paradas,

María Torrecillas-López,

Luna Barrera-Chamorro

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

The gut microbiota has co-evolved with its host, profoundly shaping the development and functioning of immune system. This co-evolution led to a dynamic relationship where microbial metabolites molecular signals influence maturation, tolerance, defense mechanisms, highlighting essential role in maintaining host health. Recently, bacterial extracellular vesicles (BEVs), membrane nanoparticles produced by bacteria, have emerged as important players balance potent modulators. These reflect characteristics contain nucleic acids, proteins, lipids, metabolites. They can regulate processes are involved neurological metabolic diseases due their ability distribute both locally systemically, affecting responses at levels. review provides comprehensive overview functional profile BEVs, detailing how nutrition influences production function these vesicles, antibiotics disrupt or alter composition, factors collectively impact immunity disease development. It also highlights potential BEVs precision nutritional strategies through dietary modulation, such incorporating prebiotic fibers enhance beneficial BEV production, reducing intake processed foods that may promote harmful tailoring probiotic interventions specific communities vesicular outputs.

Language: Английский

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