Pathological Investigation of the Effect of Bovine Colostrum Against 5-FU-Induced Liver, Kidney, and Heart Toxicity in Rats DOI Creative Commons
Muhammet Bahaeddi̇n Dörtbudak, Muhammed Demircioğlu, İsmail Demircioğlu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 564 - 564

Published: March 31, 2025

This study aimed to investigate the possible histopathological and immunohistochemical effects of bovine colostrum (BC) against toxic 5-fluorouracil (5-FU) on liver, kidney, heart Wistar Albino rats. Animals were divided into three groups: control, 5-FU, 5-FU+BC. The control group received 2 mL/kg i.p. saline, 5-FU 100 mg/kg 5-FU+BC saline first day study. groups 1000 BC orally each Liver, tissues examined histopathologically for lesions expression TNF-α, HSP-27, CASP-3, 8-OHdG. No pathologic observed in group, whereas severe group. In less than examination, biomarker was not it At end study, that 5-FU-induced pathological findings decreased with use colostrum. difference between significant (p < 0.01 p 0.05, respectively). Although addition did show any statistical significance scores tissues, improved these tissues. Nevertheless, analyses showed visible improvements more studies are needed, is hoped will improve prognosis by both reducing side a good chemotherapeutic agent, its antineoplastic properties.

Language: Английский

Bioactivity evaluation of Polygonum minus and identification of synergistic phytochemicals with 5-fluorouracil for colon cancer treatment DOI
Zhongming Yang, Zhongguo Yang, Md Zuki Abu Bakar

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112917 - 112917

Published: Jan. 30, 2025

Language: Английский

Citations

2
Diacerein's Antiproliferative Effects Alone and with 5-Fluorouracil in an Ehrlich Solid Tumour Model: Molecular Docking, Molecular Dynamics Simulation Studies, and Experimental Verification DOI
Mohamed S. Abdel‐Maksoud,

Renad Abdullah Altai,

Sarah Saad A Albalawi

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177564 - 177564

Published: March 1, 2025

Language: Английский

Citations

0
Pathological Investigation of the Effect of Bovine Colostrum Against 5-FU-Induced Liver, Kidney, and Heart Toxicity in Rats DOI Creative Commons
Muhammet Bahaeddi̇n Dörtbudak, Muhammed Demircioğlu, İsmail Demircioğlu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 564 - 564

Published: March 31, 2025

This study aimed to investigate the possible histopathological and immunohistochemical effects of bovine colostrum (BC) against toxic 5-fluorouracil (5-FU) on liver, kidney, heart Wistar Albino rats. Animals were divided into three groups: control, 5-FU, 5-FU+BC. The control group received 2 mL/kg i.p. saline, 5-FU 100 mg/kg 5-FU+BC saline first day study. groups 1000 BC orally each Liver, tissues examined histopathologically for lesions expression TNF-α, HSP-27, CASP-3, 8-OHdG. No pathologic observed in group, whereas severe group. In less than examination, biomarker was not it At end study, that 5-FU-induced pathological findings decreased with use colostrum. difference between significant (p < 0.01 p 0.05, respectively). Although addition did show any statistical significance scores tissues, improved these tissues. Nevertheless, analyses showed visible improvements more studies are needed, is hoped will improve prognosis by both reducing side a good chemotherapeutic agent, its antineoplastic properties.

Language: Английский

Citations

0