Effectiveness of African Herbal Preparations against Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review DOI Creative Commons

Rachel Ama Adadziwa Akorful,

Karikari Asafo-Adjei, Fleischer C. N. Kotey

et al.

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02644 - e02644

Published: March 1, 2025

Language: Английский

Discovery of Isobavachin, a natural flavonoid, as an Apolipo-protein E4 (ApoE4) structure corrector for Alzheimer’s disease DOI Creative Commons
Sachin Patil,

Bella R. Kuehn,

Christina McCullough

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) the strongest genetic risk factor for AD, with its pathological effects linked to structural instability altered interactions lipids other important proteins including amyloid beta (Aβ) tau (τ). Therefore, correcting stabilizing ApoE4 structure has emerged as promising therapeutic strategy mitigating detrimental effects. In this study, we investigated naturally occurring bioavailable flavonoids stabilizers, focusing on their potential modulate function. Comprehensive investigation of focused database using our integrated computational experimental screening protocol led identification Isobavachin corrector stabilizer structure. addition, few similar properties were identified, albeit much lesser extent compared Isobavachin. The findings support modulators highlight lead candidate further preclinical evaluation. These results provide new insights into pharmacological targeting open avenues development flavonoid-based, ApoE-directed therapies AD.

Language: Английский

Citations

0
Discovery of Isobavachin, a Natural Flavonoid, as an Apolipoprotein E4 (ApoE4) Structure Corrector for Alzheimer’s Disease DOI Creative Commons
Sachin Patil,

Bella R. Kuehn,

Christina McCullough

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 940 - 940

Published: Feb. 18, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) the strongest genetic risk factor for AD, with its pathological effects linked to structural instability altered interactions lipids other important proteins including amyloid beta (Aβ) tau (τ). Therefore, correcting stabilizing ApoE4 structure has emerged as promising therapeutic strategy mitigating detrimental effects. In this study, we investigated naturally occurring bioavailable flavonoids stabilizers, focusing on their potential modulate function. A comprehensive investigation of focused database using our integrated computational experimental screening protocol led identification Isobavachin corrector stabilizer structure. addition, few similar properties were identified, albeit much lesser extent compared Isobavachin. The findings support modulators highlight lead candidate further preclinical evaluation. These results provide new insights into pharmacological targeting open avenues development flavonoid-based, ApoE-directed therapies AD.

Language: Английский

Citations

0
Plant Secondary Metabolites in Defense Against Phytopathogens: Mechanisms, Biosynthesis, and Applications DOI
Punet Kumar, Deepak Kumar,

Sushma Pal

et al.

Physiological and Molecular Plant Pathology, Journal Year: 2025, Volume and Issue: 138, P. 102639 - 102639

Published: March 1, 2025

Language: Английский

Citations

0
Effectiveness of African Herbal Preparations against Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review DOI Creative Commons

Rachel Ama Adadziwa Akorful,

Karikari Asafo-Adjei, Fleischer C. N. Kotey

et al.

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02644 - e02644

Published: March 1, 2025

Language: Английский

Citations

0