Association Between Healthy Lifestyle and Cognitive Function in Middle-Aged and Older Adults DOI Open Access
Rouba Khalil Naaman, Shoug Alashmali,

Manar Abduljalil Bakhsh

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(10), P. 1140 - 1140

Published: May 14, 2025

Background/Objectives: The adherence to a healthy lifestyle is important for supporting cognitive function as aging progresses. This study aimed assess the association between lifestyle, specifically diet quality, physical activity, and smoking, in middle-aged older adults. Methods: A cross-sectional was conducted among participants aged 45 with normal cognition. Participants’ performance assessed by Montreal Cognitive Assessment (MoCA). Dietary intake using 24 h dietary recall, quality Diet Quality Index-International (DQI-I). Physical activity International Activity Questionnaire (IPAQ). Participants were categorized unhealthy (score ≤ 1), average 2), 3). Results: In this study, total of 176 recruited, 46% them classified unhealthy, 40% average, 14% healthy. group had lower naming domain compared other groups (p = 0.01). scored significantly than orientation 0.02). Performing moderate high levels associated higher scores MoCA 0.04) Conclusions: Adopting maintaining health adults, relevance multidomain interventions. Further longitudinal research warranted evaluate long-term feasibility effectiveness interventions population.

Language: Английский

Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review DOI Open Access
Alex Graça Contato, Carlos Adam Conté-Júnior

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1307 - 1307

Published: April 9, 2025

Hericium erinaceus, commonly known as lion’s mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview the nutritional therapeutic potential H. with particular focus on anti-inflammatory, antioxidant, antimicrobial activities. A structured literature search was performed using databases such PubMed, Scopus, Science Direct, Web Science, Google Scholar. Studies published in last two decades focusing erinaceus’ were included. The chemical erinaceus includes polysaccharides, terpenoids (hericenones erinacines), phenolic compounds, which exhibit potent antioxidant effects by scavenging reactive oxygen species (ROS) inducing endogenous enzymes. Additionally, shows promising activity against bacterial fungal pathogens, applications combating antibiotic-resistant infections. mushroom’s capacity stimulate nerve growth factor (NGF) synthesis highlighted preventing managing neurodegenerative diseases, Alzheimer’s Parkinson’s. Advances biotechnological methods, including optimized cultivation techniques novel extraction may further enhance bioavailability pharmacological erinaceus. Despite findings, clinical validation remains limited. Future research should prioritize large-scale trials, standardization elucidation pharmacokinetics facilitate integration into evidence-based medicine. functional food, nutraceutical, adjunct agent highlights need for interdisciplinary collaboration between researchers, clinicians, regulatory bodies.

Language: Английский

Citations

1
fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura DOI Creative Commons

Damian Pikor,

Natalia Banaszek-Hurła,

Alicja Drelichowska

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(2), P. 15 - 15

Published: Jan. 21, 2025

Migraine with aura (MwA) is a common and severely disabling neurological disorder, characterised by transient yet recurrent visual disturbances, including scintillating scotomas, flickering photopsias, complex geometric patterns. These episodic phenomena significantly compromise daily functioning, productivity, overall quality of life. Despite extensive research, the underlying pathophysiological mechanisms remain only partially understood. Cortical spreading depression (CSD), propagating wave neuronal glial depolarisation, has been identified as central process in MwA. This phenomenon triggered ion channel dysfunction, leading to elevated intracellular calcium levels excessive glutamate release, which contribute widespread cortical hyperexcitability. Genetic studies, particularly involving CACNA gene family, further implicate dysregulation channels pathogenesis Recent advances neuroimaging, functional magnetic resonance imaging (fMRI), have provided critical insights into neurophysiology results support role CSD basic mechanism behind MwA imply that dysfunction endures beyond brief episodes, possibly due chronic or The cortex patients exhibits activation patterns comparison other neuroimaging supporting possibility it disease-specific biomarker. Its distinctive sensory cognitive characteristics are influenced interplay cortical, vascular, genetic factors, demonstrating multifactorial nature We now know much more about pathophysiology thanks combination molecular research sophisticated techniques like arterial spin labelling (ASL) fMRI. review aims synthesize current knowledge analyse neurophysiological targets, providing foundation for developing targeted therapies modulate excitability, restore neural network stability, alleviate burden migraine aura. most important impactful our field focus this review, highlights developments their contributions treatment

Language: Английский

Citations

0
Gallic acid alleviates Alzheimer's disease by inhibiting p38/MAPK signaling pathway DOI
Jiaxin Wang, Qingling Wang,

Xiao Tu

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106745 - 106745

Published: March 21, 2025

Language: Английский

Citations

0
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathway DOI
Zhili Chu, Yubing Chen,

Danni Xie

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119879 - 119879

Published: April 1, 2025

Language: Английский

Citations

0
Advances in magnetic field approaches for non-invasive targeting neuromodulation DOI Creative Commons
Mozhgan Alipour,

Maryam Abdolmaleki,

Yaser Shabanpour

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 28, 2025

Neuromodulation, the targeted regulation of nerve activity, has emerged as a promising approach for treating various neurological and psychiatric disorders. While deep brain stimulation shown efficacy, its invasive nature poses substantial risks, including surgical complications high costs. In contrast, non-invasive neuromodulation techniques, particularly those utilizing magnetic fields (MFs), have gained increasing attention safer, more accessible alternatives. Magnetothermal an innovative method that enables precise modulation neuronal ion channels through localized heating induced by interaction MF with biological tissues. This review discusses principles MF-based highlights critical role in synaptic transmission, therapeutic potential these advanced techniques. Additionally, it key challenges such spatial targeting precision, safety considerations, long-term effects exposure on function. The findings presente promise non-invasive, highly strategy conditions epilepsy, movement disorders, neurodegenerative diseases, applications chronic pain management future clinical interventions.

Language: Английский

Citations

0
Neuronal calcium signaling: Mechanisms, function and clinical implications in neurological diseases DOI
Weining Zhu, Shuai Xiao

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 30, 2025

The neuronal calcium signaling plays a pivotal role in maintaining function and orchestrating neural network activity. As key second messenger, ions (Ca²⁺) participate broad spectrum of intra- extracellular processes, influencing essential physiological functions such as synaptic transmission, excitability, gene expression, cell fate determination. This review aims to provide an overview the fundamental mechanisms underlying signaling, including sources regulation intracellular calcium, associated cascades, their termination pathways. Furthermore, it will analyze specific functional roles neurons elucidate its intricate regulatory mechanisms, involvement channels receptors, calcium-binding proteins, pumps exchangers. Particular emphasis be placed on implications dysregulation neurological diseases Alzheimer’s disease (AD), Parkinson’s (PD), epilepsy. In addition, this examine emerging clinical applications targeting pathways, development pharmacological modulators identification novel diagnostic therapeutic targets. By integrating recent research advances theoretical developments, seeks offer detailed up-to-date understanding critical neuroscience translational relevance practice.

Language: Английский

Citations

0
Association Between Healthy Lifestyle and Cognitive Function in Middle-Aged and Older Adults DOI Open Access
Rouba Khalil Naaman, Shoug Alashmali,

Manar Abduljalil Bakhsh

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(10), P. 1140 - 1140

Published: May 14, 2025

Background/Objectives: The adherence to a healthy lifestyle is important for supporting cognitive function as aging progresses. This study aimed assess the association between lifestyle, specifically diet quality, physical activity, and smoking, in middle-aged older adults. Methods: A cross-sectional was conducted among participants aged 45 with normal cognition. Participants’ performance assessed by Montreal Cognitive Assessment (MoCA). Dietary intake using 24 h dietary recall, quality Diet Quality Index-International (DQI-I). Physical activity International Activity Questionnaire (IPAQ). Participants were categorized unhealthy (score ≤ 1), average 2), 3). Results: In this study, total of 176 recruited, 46% them classified unhealthy, 40% average, 14% healthy. group had lower naming domain compared other groups (p = 0.01). scored significantly than orientation 0.02). Performing moderate high levels associated higher scores MoCA 0.04) Conclusions: Adopting maintaining health adults, relevance multidomain interventions. Further longitudinal research warranted evaluate long-term feasibility effectiveness interventions population.

Language: Английский

Citations

0