Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

A Comprehensive Review of the Contribution of Mitochondrial DNA Mutations and Dysfunction in Polycystic Ovary Syndrome, Supported by Secondary Database Analysis DOI Open Access
Hiroshi Kobayashi, Sho Matsubara,

Chiharu Yoshimoto

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1172 - 1172

Published: Jan. 29, 2025

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age characterized by spectrum clinical, metabolic, reproductive, and psychological abnormalities. This associated with significant long-term health risks, necessitating elucidation its pathophysiology, early diagnosis, comprehensive management strategies. Several contributory factors in PCOS, including androgen excess insulin resistance, collectively enhance oxidative stress, which subsequently leads to mitochondrial dysfunction. However, the precise mechanisms through stress induces dysfunction remain incompletely understood. Comprehensive searches electronic databases were conducted identify relevant studies published up 30 September 2024. Mitochondria, primary sites reactive oxygen species (ROS) generation, play critical roles energy metabolism cellular homeostasis. Oxidative can inflict damage on components, lipids, proteins, DNA. Damage DNA (mtDNA), lacks efficient repair mechanisms, may result mutations that impair function. Dysfunctional activity further amplifies ROS production, thereby perpetuating stress. These disruptions are implicated complications syndrome. Advances genetic analysis technologies, next-generation sequencing, have identified point deletions mtDNA, drawing attention their association Emerging data from mtDNA mutation analyses challenge conventional paradigms provide new insights into role We rethinking pathogenesis PCOS based these database analyses. In conclusion, this review explores intricate relationship between mutations, dysfunction, offers an updated perspective pathophysiology outlines directions for future research.

Language: Английский

Citations

0
Exploring the Impact of Follicular Fluid Exosomes on Porcine Cumulus Cell and Oocyte Function: A Cerna Network Analysis Based on the Enssscg00000042788/Ssc-Mir-504/Pdha1 Axis DOI
Yi Jin, Junzheng Zhang,

Shuang Ji

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance DOI
Deepak Parchwani, Ragini Singh,

Digisha Patel

et al.

World Journal of Methodology, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 6, 2025

The mitochondrial DNA copy number (mtDNAcn) plays a vital role in cellular energy metabolism and health. As mitochondria are responsible for adenosine triphosphate production through oxidative phosphorylation, maintaining an appropriate mtDNAcn level is the overall function. Alterations have been linked to various diseases, including neurodegenerative disorders, metabolic conditions, cancers, making it important biomarker understanding disease pathogenesis. accurate estimation of essential clinical applications. Quantitative polymerase chain reaction next-generation sequencing commonly employed techniques with distinct advantages limitations. Clinically, serves as valuable indicator early diagnosis, progression, treatment response. For instance, oncology, elevated levels blood samples associated tumor aggressiveness can aid monitoring efficacy. In diseases such Alzheimer’s Parkinson’s, altered patterns provide insights into mechanisms progression. Understanding estimating critical advancing diagnostic therapeutic strategies medical fields. research continues uncover implications alterations, its potential likely expand, thereby enhancing our ability diagnose manage complex diseases.

Language: Английский

Citations

0
Research progress in the extraction, purification, structural features, biological activities, and structure-activity relationships from Prunella vulgaris polysaccharides DOI

Xiaopeng Ai,

Peiling Yu,

Yaqin Hou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141957 - 141957

Published: March 10, 2025

Language: Английский

Citations

0
Follicular metabolic dysfunction, oocyte aneuploidy and ovarian aging: a review DOI Creative Commons

Depei Wu,

Chuanming Liu, Lijun Ding

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 12, 2025

With the development of modern society and prolonged education, more women choose to delay their childbearing age, which greatly increases number aged older than 35 years with needs. However, increasing quantity quality oocytes continue fall, especially aneuploidy, leads a low in vitro fertilization (IVF) success rate, high abortion rate teratogenesis assisted reproduction advanced maternal age. In addition genetics epigenetics, follicular metabolism homeostasis is closely related ovarian aging oocyte aneuploidy. Glucose, lipid, amino acid not only provide energy for follicle genesis but also regulate maturation. This review focuses on relationships among metabolism, discusses potential therapeutic metabolites aging.

Language: Английский

Citations

0
Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

Citations

2