Matrix Metalloproteinases: Pathophysiologic Implications and Potential Therapeutic Targets in Cardiovascular Disease DOI Creative Commons
Daniela Maria Tănase, Emilia Valasciuc,

I. Antón

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 598 - 598

Published: April 17, 2025

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play crucial role in extracellular matrix (ECM) remodeling and implicated the pathogenesis various cardiovascular diseases (CVDs). Their dysregulation has been linked to atherosclerosis, myocardial infarction (MI), heart failure (HF), aortic stenosis, contributing vascular inflammation, plaque destabilization, adverse cardiac remodeling. Recent research highlights MMPs’ involvement beyond ECM degradation, influencing lipoprotein metabolism, inflammatory signaling, intracellular processes critical for homeostasis. Despite their pathological role, MMPs remain promising therapeutic targets, with pharmacological inhibitors, gene therapy, tissue inhibitors (TIMPs) emerging as potential interventions. However, clinical translation MMP-targeting therapies remains challenging due off-target effects complex regulatory mechanisms. This review provides an updated synthesis molecular mechanisms, disease-specific roles, implications pathology, aiming bridge gap between fundamental applications.

Language: Английский

Bioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies DOI
Hamada El‐Gendi, Jehan S. Albrahim, Hussain Alenezi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141958 - 141958

Published: March 1, 2025

Language: Английский

Citations

0
Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing DOI

Pawan Jaiswal,

Giriraj Pandey,

Shivam Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106872 - 106872

Published: April 1, 2025

Language: Английский

Citations

0
Matrix Metalloproteinases: Pathophysiologic Implications and Potential Therapeutic Targets in Cardiovascular Disease DOI Creative Commons
Daniela Maria Tănase, Emilia Valasciuc,

I. Antón

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 598 - 598

Published: April 17, 2025

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play crucial role in extracellular matrix (ECM) remodeling and implicated the pathogenesis various cardiovascular diseases (CVDs). Their dysregulation has been linked to atherosclerosis, myocardial infarction (MI), heart failure (HF), aortic stenosis, contributing vascular inflammation, plaque destabilization, adverse cardiac remodeling. Recent research highlights MMPs’ involvement beyond ECM degradation, influencing lipoprotein metabolism, inflammatory signaling, intracellular processes critical for homeostasis. Despite their pathological role, MMPs remain promising therapeutic targets, with pharmacological inhibitors, gene therapy, tissue inhibitors (TIMPs) emerging as potential interventions. However, clinical translation MMP-targeting therapies remains challenging due off-target effects complex regulatory mechanisms. This review provides an updated synthesis molecular mechanisms, disease-specific roles, implications pathology, aiming bridge gap between fundamental applications.

Language: Английский

Citations

0