The Impact and Molecular Mechanisms of Exercise in Cancer Therapy DOI Creative Commons

Yingjie Sun,

Yixiao Ma, Lei Shi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 374 - 374

Published: May 20, 2025

Cancer is a major global health issue, and exercise has become key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, aiding recovery, especially for survivors. However, the exact mechanisms, such as how reduces risk or enhances treatment, are still unclear. Current research often focuses on specific types, ignoring diverse needs of patients. This limits development personalized plans. Additionally, there insufficient comparison types—like aerobic, resistance, high-intensity interval training—regarding their adverse effects long-term benefits. The best combination exercises strategies remains unknown. review underscores contribution physical prevention emphasizing its positive fatigue, improving strength, mental health. also explores molecular mechanisms regulating tumor immunity energy metabolism. article covers criteria selecting types intensities, Finally, it provides guidelines prescriptions suggests future directions improve interventions

Language: Английский

Unraveling the Complexities of Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease DOI Open Access
Yangzhuangzhuang Zhu, Siyan Cao

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3291 - 3291

Published: April 2, 2025

Myeloid-derived suppressor cells (MDSCs) regulate immune responses in many pathological conditions, one of which is inflammatory bowel disease (IBD), an incurable chronic disorder the digestive tract and beyond. The pathophysiology IBD remains unclear, likely involving aberrant innate adaptive immunity. Studies have reported altered population MDSCs patients with IBD. However, their distribution varies among different preclinical models expansion activation are driven by various stimuli during intestinal inflammation, but in-depth mechanisms remain poorly understood. role pathogenesis appears to be paradoxical. In addition suppressive may promote colitis-to-colon cancer transition. this Review, we summarize recent progresses on features, activation, roles development IBD-associated colon cancer.

Language: Английский

Citations

0
The Impact and Molecular Mechanisms of Exercise in Cancer Therapy DOI Creative Commons

Yingjie Sun,

Yixiao Ma, Lei Shi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 374 - 374

Published: May 20, 2025

Cancer is a major global health issue, and exercise has become key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, aiding recovery, especially for survivors. However, the exact mechanisms, such as how reduces risk or enhances treatment, are still unclear. Current research often focuses on specific types, ignoring diverse needs of patients. This limits development personalized plans. Additionally, there insufficient comparison types—like aerobic, resistance, high-intensity interval training—regarding their adverse effects long-term benefits. The best combination exercises strategies remains unknown. review underscores contribution physical prevention emphasizing its positive fatigue, improving strength, mental health. also explores molecular mechanisms regulating tumor immunity energy metabolism. article covers criteria selecting types intensities, Finally, it provides guidelines prescriptions suggests future directions improve interventions

Language: Английский

Citations

0