Androgen Receptors in Human Breast Cancer and Female Canine Mammary Tumors DOI Creative Commons
Vladimir Vidović, Ivana Davidov, Zoran Ružić

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1411 - 1411

Published: March 22, 2025

This review explores the potential role of androgens in human breast cancer and female canine mammary tumors. Human is one most common cancers affecting women globally, while tumors provide a natural model for study due to their similar histopathologies molecular features. Androgen receptors, typically linked male sex hormones, are present up 90% These receptors interact with estrogen-receptor signaling, suggesting involvement complex mechanism progression. have become key players biology, offering new targets therapeutic strategies. The presence these both raises important questions about development malignancies. While exact mechanisms remain be fully elucidated, research suggests that targeting androgen-receptor signaling could novel approach humans canines. Further studies necessary understand implications expression develop more effective targeted therapies cancers.

Language: Английский

Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies DOI Creative Commons
Mingyao Huang, Yikai Zhang,

Zhaoji Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 215, P. 107726 - 107726

Published: April 4, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of with limited treatment options and poor prognosis. The gut microbiota, a diverse community microorganisms in the gastrointestinal tract, plays crucial role regulating immune responses through gut-immune axis. Recent studies have highlighted its significant impact on TNBC progression efficacy immunotherapies. This review examines interactions between microbiota system TNBC, focusing key cells pathways involved tumor immunity. It also explores modulation strategies, including probiotics, prebiotics, dietary interventions, fecal transplantation, as potential methods to enhance immunotherapeutic outcomes. Understanding these mechanisms offers promising avenues for improving patient prognosis TNBC.

Language: Английский

Citations

0
Androgen Receptors in Human Breast Cancer and Female Canine Mammary Tumors DOI Creative Commons
Vladimir Vidović, Ivana Davidov, Zoran Ružić

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1411 - 1411

Published: March 22, 2025

This review explores the potential role of androgens in human breast cancer and female canine mammary tumors. Human is one most common cancers affecting women globally, while tumors provide a natural model for study due to their similar histopathologies molecular features. Androgen receptors, typically linked male sex hormones, are present up 90% These receptors interact with estrogen-receptor signaling, suggesting involvement complex mechanism progression. have become key players biology, offering new targets therapeutic strategies. The presence these both raises important questions about development malignancies. While exact mechanisms remain be fully elucidated, research suggests that targeting androgen-receptor signaling could novel approach humans canines. Further studies necessary understand implications expression develop more effective targeted therapies cancers.

Language: Английский

Citations

0