Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea DOI Creative Commons
Juan Ortega‐Vidal, Maggie M. Reddy, Nadia Pérez-Fuentes

et al.

Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Sponges of the genus Neopetrosia are known for production a large diversity bioactive metabolites. Contignasterines A (1) and B (2) were isolated as major metabolites sponge cf. rava collected in Bismarck Sea along with highly steroid contignasterol (3) possessing similar oxidized aglycone. characterized by presence 2-aminoimidazole branched on side-chains steroid, 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities these compounds investigated revealed that all three inhibited pro-inflammatory mediators.

Language: Английский

Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea DOI Creative Commons
Juan Ortega‐Vidal, Maggie M. Reddy, Nadia Pérez-Fuentes

et al.

Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Sponges of the genus Neopetrosia are known for production a large diversity bioactive metabolites. Contignasterines A (1) and B (2) were isolated as major metabolites sponge cf. rava collected in Bismarck Sea along with highly steroid contignasterol (3) possessing similar oxidized aglycone. characterized by presence 2-aminoimidazole branched on side-chains steroid, 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities these compounds investigated revealed that all three inhibited pro-inflammatory mediators.

Language: Английский

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