Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study DOI Creative Commons

Hua Jun Liang,

Q Wu, Shu Yang

et al.

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2191 - 2201

Published: April 1, 2025

Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed investigate whether potential risk factors have causal effect on NP at the genetic level using two-sample Mendelian randomization (MR) analysis. Summary-level data for factors, including distress, anxiety disorder, depression, mood, sleep loneliness, education, alcohol consumption, smoking, time spent computer, and physical activity, as well NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) extracted these datasets. We employed inverse variance weighting (IVW), weighted median, MR-Egger regression methods assess effects. Heterogeneity was evaluated IVW, while horizontal pleiotropy assessed MR-PRESSO analysis regression. The IVW results showed major depressive (OR = 1.51, 95% CI: 1.15, 1.98, p 3.40×10-3) experiencing mood swings 2.73, 1.57, 4.75, 3.86×10-4) positively associated with years of schooling 0.504, 0.410, 0.619, 6.55×10-11) negatively NP. Additionally, loneliness 16.0, 1.29-198, 0.0307) suggestive association As other we did not find clear relationship (All p-values > 0.05). MR provides evidence supporting between swings, association. These findings highlight critical role psychosocial such education level, in prevention management Our may offer new insights clinicians develop targeted intervention strategies reducing incidence

Language: Английский

An association study of multimodal neuroimage features and gene expression in adolescents with centrally mediated abdominal pain syndrome DOI
Qihan Li, Qian Huang, Bin Zhao

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study DOI Creative Commons

Hua Jun Liang,

Q Wu, Shu Yang

et al.

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2191 - 2201

Published: April 1, 2025

Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed investigate whether potential risk factors have causal effect on NP at the genetic level using two-sample Mendelian randomization (MR) analysis. Summary-level data for factors, including distress, anxiety disorder, depression, mood, sleep loneliness, education, alcohol consumption, smoking, time spent computer, and physical activity, as well NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) extracted these datasets. We employed inverse variance weighting (IVW), weighted median, MR-Egger regression methods assess effects. Heterogeneity was evaluated IVW, while horizontal pleiotropy assessed MR-PRESSO analysis regression. The IVW results showed major depressive (OR = 1.51, 95% CI: 1.15, 1.98, p 3.40×10-3) experiencing mood swings 2.73, 1.57, 4.75, 3.86×10-4) positively associated with years of schooling 0.504, 0.410, 0.619, 6.55×10-11) negatively NP. Additionally, loneliness 16.0, 1.29-198, 0.0307) suggestive association As other we did not find clear relationship (All p-values > 0.05). MR provides evidence supporting between swings, association. These findings highlight critical role psychosocial such education level, in prevention management Our may offer new insights clinicians develop targeted intervention strategies reducing incidence

Language: Английский

Citations

0