Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 19, 2025

Language: Английский

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Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

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Special Issue “Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota 2.0”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1081 - 1081

Published: Jan. 26, 2025

This Special Issue of the International Journal Molecular Sciences focuses on highly relevant and rapidly developing topic gut microbiota research [...]

Language: Английский

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