Mitochondrial microRNAs (mitomiRs) as emerging biomarkers and therapeutic targets for chronic human diseases DOI Creative Commons

Andrea Méndez-García,

Marely Abigail García-Mendoza,

Carmila Patricia Zárate-Peralta

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Mitochondria are membrane-bound cell organelles that undertake the majority of energetic and metabolic processes within cell. They also responsible for mediating multiple apoptotic pathways, balancing redox charges, scavenging reactive oxygen species. MicroRNAs, which short, non-coding RNAs widely known regulating gene expression at post-transcriptional level, regulate many these processes. The specific microRNAs directly or indirectly control mitochondrial dynamics called miRNAs (mitomiRs). broadest classification this type ncRNA encompasses nuclear-encoded interact with cytoplasmatic mRNAs associated activity. At same time, a more subset comprises translocate into mitochondria to inside organelle. Finally, smallest group mitomiRs includes those codified by mtDNA can endogenous transcripts be transported cytoplasm modulate circulating mRNAs. Regardless origin action mechanism, have been recently recognized key role in progression variety chronic disorders, such as neurodegenerative cardiovascular diseases, diabetes, asthma, depression, even cancer. All progressive pathologies tightly linked dysregulation. further an aberrant cellular metabolism, positioning reliable biomarkers diagnosing several diseases. These molecular indicators provided insights how conditions progress, allowing development different miRNA-based treatment strategies target dysregulated mitochondrial-related genes, reestablishing their baseline activity restricting disease progression.

Language: Английский

Disrupted Mitochondrial Dynamics Impair Corneal Epithelial Healing in Neurotrophic Keratopathy DOI Open Access

Mengyi Jin,

Zeyu Liu, Ruize Shi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1290 - 1290

Published: Feb. 3, 2025

Neurotrophic keratopathy (NK) is a degenerative corneal disease characterized by impaired sensitivity and epithelial repair that often linked to sensory nerve dysfunction. To establish clinically relevant model explore the mechanisms underlying NK pathogenesis, we developed novel mouse through partial transection of ciliary nerve. This approach mimics progressive nature NK, reproducing key clinical features such as defects, reduced sensitivity, diminished tear secretion, delayed wound healing. Using this model, investigated how disruptions in mitochondrial dynamics contribute dysfunction NK. Our findings revealed substantial dynamics, including expression fusion proteins (OPA1), downregulation fission regulators (FIS1 MFF), transport, evidenced decreased Rhot1 Kif5b. Additionally, mitophagy-related genes (Pink1 Prkn) contributed accumulation dysfunctional mitochondria, leading DNA damage repair. These abnormalities were accompanied increased γH2AX staining, indicative double-strand breaks cellular stress. study highlights pivotal role health repair, suggesting therapeutic strategies aimed at restoring function, enhancing mitophagy, mitigating oxidative stress may offer promising avenues for treating

Language: Английский

Citations

0
Mitochondrial microRNAs (mitomiRs) as emerging biomarkers and therapeutic targets for chronic human diseases DOI Creative Commons

Andrea Méndez-García,

Marely Abigail García-Mendoza,

Carmila Patricia Zárate-Peralta

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Mitochondria are membrane-bound cell organelles that undertake the majority of energetic and metabolic processes within cell. They also responsible for mediating multiple apoptotic pathways, balancing redox charges, scavenging reactive oxygen species. MicroRNAs, which short, non-coding RNAs widely known regulating gene expression at post-transcriptional level, regulate many these processes. The specific microRNAs directly or indirectly control mitochondrial dynamics called miRNAs (mitomiRs). broadest classification this type ncRNA encompasses nuclear-encoded interact with cytoplasmatic mRNAs associated activity. At same time, a more subset comprises translocate into mitochondria to inside organelle. Finally, smallest group mitomiRs includes those codified by mtDNA can endogenous transcripts be transported cytoplasm modulate circulating mRNAs. Regardless origin action mechanism, have been recently recognized key role in progression variety chronic disorders, such as neurodegenerative cardiovascular diseases, diabetes, asthma, depression, even cancer. All progressive pathologies tightly linked dysregulation. further an aberrant cellular metabolism, positioning reliable biomarkers diagnosing several diseases. These molecular indicators provided insights how conditions progress, allowing development different miRNA-based treatment strategies target dysregulated mitochondrial-related genes, reestablishing their baseline activity restricting disease progression.

Language: Английский

Citations

0