Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph DOI Creative Commons
Victoria A. Blaho,

Joshua T. Minyard

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Members of the diverse family sphingolipids (SPL), such as ceramides (Cer) and sphingomyelins (SM), are well-known structural bioactive signaling molecules. A key SPL member critical lipid, sphingosine 1-phosphate (S1P), is carried in blood primarily by its “chaperone” protein apolipoprotein M (ApoM) on high-density lipoprotein (HDL) particles. S1P has been shown to regulate biological pathways through specific G protein-coupled receptor (GPCR) that can be modulated based upon chaperone: ApoM or albumin. Blood concentrations itself altered human diseases coronary artery disease, type I II diabetes, systemic lupus erythematosus, have also linked changes other species; however, studies measuring molecules only while neglecting lymph may excluding clues physiology affected multiorgan metabolic pathways. Comparing SM, dihydroSM, Cer, dihydroCer, α-hydroxy Cer (αOHCer), (C1P), (Sph)/dihydroSph, S1P/dihydroS1P, diacylglycerol (DAG) wild-type mouse plasmas with those mice lacking expressing a transgene ApoM, we describe unanticipated differences between sphingolipidomes their ApoM-responsive lipid species. Of 100 unique species targeted, 97 were identified 94 lymph. Some most striking findings lymph, where αOHCer previously unidentified major constituent. This report provides resource starting point for further investigations into contributions circulating sphingolipidome homeostasis disease.

Language: Английский

Gangliosides and Cholesterol: Dual Regulators of Neuronal Membrane Framework in Autism Spectrum Disorder DOI Open Access
Borna Puljko,

Marija Štracak,

Svjetlana Kalanj Bognar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1322 - 1322

Published: Feb. 4, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental with heterogeneous clinical presentation. Diagnosing ASD complex, and the criteria for diagnosis, as well term ASD, have changed during last decades. Diagnosis made based on observation accomplishment of specific diagnostic criteria, while particular biomarker does not yet exist. However, studies universally report disequilibrium in membrane lipid content, pointing to unique neurolipid signature ASD. This review sheds light possible role cholesterol gangliosides, complex glycosphingolipids, development In addition maintaining integrity, neuronal signaling, synaptic plasticity, these lipids play neurotransmitter release calcium signaling. Evidence linking lipidome changes includes low levels, unusual ganglioside metabolic profiles. symptoms may be mitigated therapeutic interventions targeting composition membranes. restoring equilibrium central nervous system remains challenge. underscores need comprehensive research into metabolism uncover practical insights etiology treatment lipidomics emerges major area research.

Language: Английский

Citations

0
The Bioactive Sphingolipid Playbook. A Primer for the Uninitiated as well as Sphingolipidologists DOI Creative Commons
Yusuf A. Hannun, Alfred H. Merrill,

Chiara Luberto

et al.

Journal of Lipid Research, Journal Year: 2025, Volume and Issue: unknown, P. 100813 - 100813

Published: April 1, 2025

Language: Английский

Citations

0
Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph DOI Creative Commons
Victoria A. Blaho,

Joshua T. Minyard

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Members of the diverse family sphingolipids (SPL), such as ceramides (Cer) and sphingomyelins (SM), are well-known structural bioactive signaling molecules. A key SPL member critical lipid, sphingosine 1-phosphate (S1P), is carried in blood primarily by its “chaperone” protein apolipoprotein M (ApoM) on high-density lipoprotein (HDL) particles. S1P has been shown to regulate biological pathways through specific G protein-coupled receptor (GPCR) that can be modulated based upon chaperone: ApoM or albumin. Blood concentrations itself altered human diseases coronary artery disease, type I II diabetes, systemic lupus erythematosus, have also linked changes other species; however, studies measuring molecules only while neglecting lymph may excluding clues physiology affected multiorgan metabolic pathways. Comparing SM, dihydroSM, Cer, dihydroCer, α-hydroxy Cer (αOHCer), (C1P), (Sph)/dihydroSph, S1P/dihydroS1P, diacylglycerol (DAG) wild-type mouse plasmas with those mice lacking expressing a transgene ApoM, we describe unanticipated differences between sphingolipidomes their ApoM-responsive lipid species. Of 100 unique species targeted, 97 were identified 94 lymph. Some most striking findings lymph, where αOHCer previously unidentified major constituent. This report provides resource starting point for further investigations into contributions circulating sphingolipidome homeostasis disease.

Language: Английский

Citations

0