Construction of a novel prognostic model based on lncRNAs-related to DNA damage repair for predicting the prognosis of clear cell renal cell carcinoma
Annals of Medicine,
Journal Year:
2025,
Volume and Issue:
57(1)
Published: April 2, 2025
CcRCC
has
the
characteristics
of
high
aggression,
metastasis,
mortality,
wide
tumour
heterogeneity
and
variable
clinical
course.
The
purpose
this
study
was
to
explore
potential
value
lncRNAs-related
DNA
damage
repair
(DDR)
in
predicting
prognosis
ccRCC
by
construction
verification
a
novel
prognostic
model.
RNA-seq
data
were
downloaded
from
public
databases.
Subsequently,
Pearson
correlation
analysis
differential
expression
performed
identify
DElncRNAs-related
DDR.
Then,
through
univariate
Cox
LASSO
analysis,
DDR
associated
with
screened
for
risk
score
In
addition,
functional
annotation,
mutation
burden,
immune
drug
sensitivity
analyses
based
on
assess
patients
different
groups.
Based
four
best
selected.
model
these
DElncRNAs
constructed
LASSO.
Multivariate
showed
that
age
independent
factors
(p
<
0.05).
Functional
enrichment
DDR-related
biological
processes
mainly
enriched
group.
highly
mutated
genes
low
groups
same
(VHL,
PBRM1
TTN),
but
they
also
had
their
own
unique
genes.
significantly
0.05)
positively
correlated
infiltration
degree
CD8
T
cells
evaluated
six
algorithms.
it
found
sensitivities
drugs
Etoposide,
Imatinib,
Sorafenib,
Bosutinib
Sunitinib.
A
satisfactory
accuracy
survival
patients.
Language: Английский
Cancer and Traditional Medicine: An Integrative Approach
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(5), P. 644 - 644
Published: April 28, 2025
Despite
numerous
advances
in
treatment,
cancer
still
remains
a
leading
cause
of
death
worldwide.
Given
the
significant
health
and
economic
burden
this
disease
imposes,
it
is
important
to
explore
more
effective
treatment
strategies.
A
major
drawback
conventional
therapies
persistence
drug
resistance,
adverse
reactions
chemotherapy,
digestive
damage,
reduced
quality
life,
high
costs.
To
address
these
challenges,
researchers
have
been
investigating
utility
using
complementary
alternative
medicine
(CAM)
alongside
treatments.
Some
CAM
approaches
reported
enhance
patients’
life
reduce
severity
effects
from
therapies.
This
review
explores
traditional
Chinese,
Korean,
Indian,
Japanese,
South
African
medicines
as
supportive
for
We
also
discuss
concept
integrative
oncology
its
global
relevance,
typically
emphasize
whole-person
care,
including
diet,
lifestyle,
mental/emotional
well-being.
In
addition,
we
identify
key
active
phytochemicals
herbal
used
systems
treatment.
Our
discussion
aims
provide
foundation
future
research
into
oncology,
fostering
an
interdisciplinary
approach
management.
Language: Английский