An Autocrine Regulator Loop Involving Tumor Necrosis Factor and Chemokine (C-C motif) Ligand-2 Is Activated by Transforming Growth Factor-β in Rat Basophilic Leukemia-2H3 Mast Cells DOI Open Access
Dulce Ávila-Rodríguez, Alfredo Ibarra-Sánchez,

Marcela Sosa‐Garrocho

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4263 - 4263

Published: April 30, 2025

TGF-β is a pleiotropic cytokine with both stimulatory and inhibitory effects on immune cells, depending the microenvironmental context. It targets mast cells (MCs) in different physio-pathological conditions, such as inflammation cancer. Besides acting potent chemoattractant for MCs, regulates many other aspects of MCs’ physiology, including secretion regulatory molecules. MCs secrete variety mediators, either pre-formed or newly synthesized, upon appropriate stimulation. CCL-2 chemokine TNF act chemoattractants several participate initiation inflammatory responses by recruiting them to injured tissues. cell types under distinct cellular contexts. Here, we report that treatment alone induces synthesized rat RBL-2H3 but not mouse bone marrow-derived (BMMCs). TGF-β-induced depends rapid rearrangements actin cytoskeleton and, remarkably, early soluble triggers an autocrine signaling. In conclusion, found cooperation between signaling pathways promote cell-context specific manner.

Language: Английский

Neurogenic Inflammation in Allergic Contact Dermatitis DOI Creative Commons
Ernesto Aitella, Massimo De Martinis, Ciro Romano

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 656 - 656

Published: March 7, 2025

Allergic contact dermatitis (ACD) is a skin condition characterized by inflammation resulting from hypersensitivity upon with certain allergens. Although ACD an immune-mediated pathomechanism, the involvement of nervous system in this has increasingly been considered, particularly amplification and persistence inflammation. This paper aims to present comprehensive overview mechanisms involved neurogenic ACD, focusing on role sensory neurons, release neuropeptides, their interaction immune cells, potential therapeutic implications related pathways, diversified age gender. Innovative therapies for including topical formulations, may target mass-bound X2 G-protein-coupled receptor (MRGPRX2) endocannabinoid systems.

Language: Английский

Citations

0
An Autocrine Regulator Loop Involving Tumor Necrosis Factor and Chemokine (C-C motif) Ligand-2 Is Activated by Transforming Growth Factor-β in Rat Basophilic Leukemia-2H3 Mast Cells DOI Open Access
Dulce Ávila-Rodríguez, Alfredo Ibarra-Sánchez,

Marcela Sosa‐Garrocho

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4263 - 4263

Published: April 30, 2025

TGF-β is a pleiotropic cytokine with both stimulatory and inhibitory effects on immune cells, depending the microenvironmental context. It targets mast cells (MCs) in different physio-pathological conditions, such as inflammation cancer. Besides acting potent chemoattractant for MCs, regulates many other aspects of MCs’ physiology, including secretion regulatory molecules. MCs secrete variety mediators, either pre-formed or newly synthesized, upon appropriate stimulation. CCL-2 chemokine TNF act chemoattractants several participate initiation inflammatory responses by recruiting them to injured tissues. cell types under distinct cellular contexts. Here, we report that treatment alone induces synthesized rat RBL-2H3 but not mouse bone marrow-derived (BMMCs). TGF-β-induced depends rapid rearrangements actin cytoskeleton and, remarkably, early soluble triggers an autocrine signaling. In conclusion, found cooperation between signaling pathways promote cell-context specific manner.

Language: Английский

Citations

0