Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer DOI Creative Commons

Iqra Attique,

Zahra Haider,

Maha Khan

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(10)

Published: May 1, 2025

ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute their production. Cancer cells typically exhibit elevated levels due disrupted redox homeostasis, characterized by an imbalance between antioxidant and oxidant species. play dual role in cancer biology: at moderate levels, they facilitate tumor progression regulating oncogenes suppressor genes, inducing mutations, promoting proliferation, extracellular matrix remodeling, invasion, immune modulation, angiogenesis. However, excessive cause damage initiate apoptosis, necroptosis, or ferroptosis. Methods This review explores molecular targets involved homeostasis dysregulation examines impact on microenvironment (TME). Literature recent vitro vivo studies was analyzed assess how modulation contributes development therapy. Results Findings indicate that influence through pathways mechanisms. Targeting synthesis enhancing accumulation has shown promising anticancer effects. These therapeutic strategies significant potential impair growth while interacting with elements TME. Conclusion The serve as both promoters suppressors depending intracellular concentration. Their complex offers valuable opportunities for targeted therapies. challenges remain precisely modulating benefit, hold promise synergistic agents alongside conventional treatments, opening new avenues management.

Language: Английский

MicroRNAs in the Mitochondria–Telomere Axis: Novel Insights into Cancer Development and Potential Therapeutic Targets DOI Open Access
José Alfonso Cruz-Ramos,

Emmanuel De La Mora-Jiménez,

Beatriz Alejandra Llanes-Cervantes

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 268 - 268

Published: Feb. 25, 2025

The mitochondria–telomere axis is recognized as an important factor in the processes of metabolism, aging and oncogenesis. MicroRNAs (miRNAs) play essential function this complex interaction, having impact on aspects such cellular homeostasis, oxidative responses apoptosis. In recent years, miRNAs have been found to be crucial for telomeric stability, well mitochondrial behavior, factors that influence cell proliferation viability. Furthermore, (mitomiRs) are associated with gene expression activity cGAS/STING pathway activity, linking DNA recognition immune system responses. Hence, maintain a link biogenesis, metabolic changes cancer organelles. This review focuses roles variety progression their potential application biomarkers or therapeutic agents.

Language: Английский

Citations

0
Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer DOI Creative Commons

Iqra Attique,

Zahra Haider,

Maha Khan

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(10)

Published: May 1, 2025

ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute their production. Cancer cells typically exhibit elevated levels due disrupted redox homeostasis, characterized by an imbalance between antioxidant and oxidant species. play dual role in cancer biology: at moderate levels, they facilitate tumor progression regulating oncogenes suppressor genes, inducing mutations, promoting proliferation, extracellular matrix remodeling, invasion, immune modulation, angiogenesis. However, excessive cause damage initiate apoptosis, necroptosis, or ferroptosis. Methods This review explores molecular targets involved homeostasis dysregulation examines impact on microenvironment (TME). Literature recent vitro vivo studies was analyzed assess how modulation contributes development therapy. Results Findings indicate that influence through pathways mechanisms. Targeting synthesis enhancing accumulation has shown promising anticancer effects. These therapeutic strategies significant potential impair growth while interacting with elements TME. Conclusion The serve as both promoters suppressors depending intracellular concentration. Their complex offers valuable opportunities for targeted therapies. challenges remain precisely modulating benefit, hold promise synergistic agents alongside conventional treatments, opening new avenues management.

Language: Английский

Citations

0