Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian Hippeastrum Species (Amaryllidaceae) as Cholinesterase Inhibitors DOI Creative Commons
María Lenny Rodríguez-Escobar, Rogéria Inês Rosa Lara, Margoth Atahuachi Burgos

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 719 - 719

Published: April 29, 2025

Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The Hippeastrum genus, particularly in Bolivia, offers significant potential novel drug discovery, emphasising need conservation further phytochemical research. Twenty-seven samples Bolivian species were investigated terms of their alkaloid profile anticholinesterase activity. analysis via GC-MS identified 48 alkaloids, displaying diverse structural groups with significance. Lycorine- Homolycorine-type predominant, H. chionedyanthum haywardii, high concentrations lycorine, promising compound. evansiarum mollevillquense contained notable quantities type relevant treatment. This study also highlights variability acetylcholinesterase butyrylcholinesterase inhibitory lara-ricoi haywardii demonstrating strong inhibition. These findings suggest that are valuable source bioactive compounds, warranting research into therapeutic applications.

Language: Английский

Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian Hippeastrum Species (Amaryllidaceae) as Cholinesterase Inhibitors DOI Creative Commons
María Lenny Rodríguez-Escobar, Rogéria Inês Rosa Lara, Margoth Atahuachi Burgos

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 719 - 719

Published: April 29, 2025

Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The Hippeastrum genus, particularly in Bolivia, offers significant potential novel drug discovery, emphasising need conservation further phytochemical research. Twenty-seven samples Bolivian species were investigated terms of their alkaloid profile anticholinesterase activity. analysis via GC-MS identified 48 alkaloids, displaying diverse structural groups with significance. Lycorine- Homolycorine-type predominant, H. chionedyanthum haywardii, high concentrations lycorine, promising compound. evansiarum mollevillquense contained notable quantities type relevant treatment. This study also highlights variability acetylcholinesterase butyrylcholinesterase inhibitory lara-ricoi haywardii demonstrating strong inhibition. These findings suggest that are valuable source bioactive compounds, warranting research into therapeutic applications.

Language: Английский

Citations

0