Action Mechanisms of Medicinal Plant Components as Antimycosis: A Literature Review DOI Creative Commons
Mohamed El‐Sakhawy,

Ghadah S. Abusalim,

Ahmed Ashour

et al.

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 5, P. 1647 - 1647

Published: March 12, 2025

Mycosis poses a significant threat to global health, particularly in immune-compromised individuals, and the rise of antifungal resistance has further complicated their treatment. The fungal infections (FIs) is growing concern, contributing significantly morbidity mortality rates. Medicinal plants (MPs), with long history use traditional medicine, have emerged as valuable source bioactive compounds potent properties. current study explores mechanisms by which plant active constituents (PACs) exert effects, including inhibition cell membrane (CM) wall (CW) synthesis, mitochondrial dysfunction, Nucleic acids (Nas) protein synthesis (PS), inhibiting electron transport chain, decreasing ATP production, glycolysis, oxidative phosphorylation, oxygen uptake cells, this lead affect division, /or its mycelial growth spore germination. Compounds such flavonoids, alkaloids, terpenoids, other PACs demonstrated activity through these diverse mechanisms, offering potential alternatives conventional drugs. This highlights MPs foundation for developing novel therapies. Furthermore, it underscores importance understanding intraocular action (MsOA) combat improve therapeutic outcomes. comprehensive analysis not only validates medicine but also provides roadmap future research drug development fight against FIs. aligns supports sustainable goals (SDGs), good health well-being (SDG 3) goals.

Language: Английский

Camellia Tea Saponin Ameliorates 5–Fluorouracil-Induced Damage of HaCaT Cells by Regulating Ferroptosis and Inflammation DOI Open Access

Tanrada Likitsatian,

Pimpisid Koonyosying, Narisara Paradee

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 764 - 764

Published: Feb. 21, 2025

Background/Objective: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation products (LPOs). A chemotherapeutic drug, 5–fluorouracil (5–FU), can induce epithelial mucositis and favor drug synergism with erastin in ferroptosis. Camellia tea saponin extract (TS) known to exert antioxidative properties. This study aims delineate the protective role TS mitigating 5–FU-induced ferroptosis inflammation human keratinocytes. Methods: HaCaT cells were induced 5–FU erastin, treated different doses, their viability was then determined. Levels cellular reactive oxygen species (ROS), LPOs, labile iron pool (LIP), glutathione (GSH), peroxidase 4 (GPX–4) activity, as well IL–6, IL–1β, TNF–α levels, wound healing properties assessed. Results: per se (at up 25 µg/mL) not toxic but unable restore baseline levels. The compound significantly diminished increases ROS, LIP, while restoring GSH content GPX–4 activity. Additionally, it suppressed cytokine production a concentration–dependent manner. Moreover, exerted wound-healing effects against skin injuries damage dose dependently. Conclusions: insights this work have identified biochemical mechanisms using protect keratinocyte inflammation. highlights promising adjunctive potential mitigation management chemotherapy-induced mucositis.

Language: Английский

Citations

1
Special Issue “Antifungal Drug Discovery: Progresses, Challenges, Opportunities” DOI Open Access
Bernhard Biersack

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2065 - 2065

Published: Feb. 27, 2025

The considerable health risks associated with fungal infections are continuously rising, thereby requiring proper and efficient antifungal treatment options [...].

Language: Английский

Citations

0
Action Mechanisms of Medicinal Plant Components as Antimycosis: A Literature Review DOI Creative Commons
Mohamed El‐Sakhawy,

Ghadah S. Abusalim,

Ahmed Ashour

et al.

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 5, P. 1647 - 1647

Published: March 12, 2025

Mycosis poses a significant threat to global health, particularly in immune-compromised individuals, and the rise of antifungal resistance has further complicated their treatment. The fungal infections (FIs) is growing concern, contributing significantly morbidity mortality rates. Medicinal plants (MPs), with long history use traditional medicine, have emerged as valuable source bioactive compounds potent properties. current study explores mechanisms by which plant active constituents (PACs) exert effects, including inhibition cell membrane (CM) wall (CW) synthesis, mitochondrial dysfunction, Nucleic acids (Nas) protein synthesis (PS), inhibiting electron transport chain, decreasing ATP production, glycolysis, oxidative phosphorylation, oxygen uptake cells, this lead affect division, /or its mycelial growth spore germination. Compounds such flavonoids, alkaloids, terpenoids, other PACs demonstrated activity through these diverse mechanisms, offering potential alternatives conventional drugs. This highlights MPs foundation for developing novel therapies. Furthermore, it underscores importance understanding intraocular action (MsOA) combat improve therapeutic outcomes. comprehensive analysis not only validates medicine but also provides roadmap future research drug development fight against FIs. aligns supports sustainable goals (SDGs), good health well-being (SDG 3) goals.

Language: Английский

Citations

0