Prognostic Impact of Klintrup–Mäkinen (KM) Score in Gastric Cancer and Its Association with Pathological Parameters DOI Creative Commons

Andreea-Raluca Cozac-Szőke,

Georgian-Nicolae Radu,

Anca Negovan

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 715 - 715

Published: April 13, 2025

Background and Objectives: Gastric cancer (GC) remains a significant global health challenge with poor prognosis. This study aimed to evaluate the association between Klintrup–Mäkinen (KM) inflammatory infiltrate grading clinicopathological features in gastric patients, investigating its potential as prognostic marker. Material Methods: retrospective analyzed 133 adenocarcinoma patients diagnosed 2020 2021 at County Clinical Hospital Târgu Mureș, Romania. Patients were divided into two groups based on KM grades: low (grades 0–1, n = 62) high 2–3, 71). Clinicopathological characteristics survival outcomes compared groups. Results: Demographic similar grades demonstrated significantly more aggressive tumor features, including higher prevalence of Borrmann classification types III-IV (75.8% vs. 54.9%, p 0.01), poorly differentiated histology (74.1% 33.8%, < 0.0001), advanced T stage (93.5% 80.2%, 0.04), lymph node involvement (87% 60.5%, 0.0008). group also exhibited rates lymphatic invasion (79% 50.7%, 0.001), venous (51.6% 30.9%, 0.02), perineural (50% 22.5%, positive surgical margins (32.2% 15.4%, 0.02). Survival analysis revealed hazard ratio 1.642 (95% CI: 1.02–2.62) for those grades. Conclusions: Low are associated poorer prognosis GC patients. The score may serve valuable, cost-effective histological marker assessing aggressiveness could aid risk stratification when applied routine H&E-stained slides. While it does not replace immunohistochemical or molecular analyses, integrating pathological assessment enhance accuracy support identifying who might benefit from immunotherapy.

Language: Английский

Prognostic Impact of Klintrup–Mäkinen (KM) Score in Gastric Cancer and Its Association with Pathological Parameters DOI Creative Commons

Andreea-Raluca Cozac-Szőke,

Georgian-Nicolae Radu,

Anca Negovan

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 715 - 715

Published: April 13, 2025

Background and Objectives: Gastric cancer (GC) remains a significant global health challenge with poor prognosis. This study aimed to evaluate the association between Klintrup–Mäkinen (KM) inflammatory infiltrate grading clinicopathological features in gastric patients, investigating its potential as prognostic marker. Material Methods: retrospective analyzed 133 adenocarcinoma patients diagnosed 2020 2021 at County Clinical Hospital Târgu Mureș, Romania. Patients were divided into two groups based on KM grades: low (grades 0–1, n = 62) high 2–3, 71). Clinicopathological characteristics survival outcomes compared groups. Results: Demographic similar grades demonstrated significantly more aggressive tumor features, including higher prevalence of Borrmann classification types III-IV (75.8% vs. 54.9%, p 0.01), poorly differentiated histology (74.1% 33.8%, < 0.0001), advanced T stage (93.5% 80.2%, 0.04), lymph node involvement (87% 60.5%, 0.0008). group also exhibited rates lymphatic invasion (79% 50.7%, 0.001), venous (51.6% 30.9%, 0.02), perineural (50% 22.5%, positive surgical margins (32.2% 15.4%, 0.02). Survival analysis revealed hazard ratio 1.642 (95% CI: 1.02–2.62) for those grades. Conclusions: Low are associated poorer prognosis GC patients. The score may serve valuable, cost-effective histological marker assessing aggressiveness could aid risk stratification when applied routine H&E-stained slides. While it does not replace immunohistochemical or molecular analyses, integrating pathological assessment enhance accuracy support identifying who might benefit from immunotherapy.

Language: Английский

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