DjCapon Affects the Neural Regeneration and Light Sensitivity via NO and Wnt5a Signaling in Planarian Dugesia japonica DOI
Wenshuo Xie,

Jicheng Qu,

Nianhong Xing

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Anti-inflammatory and antioxidant effects of baicalein: targeting Nrf2, and NFĸB in neurodegenerative disease DOI

Omkar Kumar Kuwar,

Neena Kalia

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
GLP-1 Receptor Agonists and Myocardial Perfusion: Bridging Mechanisms to Clinical Outcomes DOI Open Access
Paschalis Karakasis, Dimitrios Patoulias, Panagiotis Theofilis

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3050 - 3050

Published: March 26, 2025

Coronary microvascular dysfunction (CMD) is a key contributor to myocardial ischemia and adverse cardiovascular outcomes, particularly in individuals with metabolic disorders such as type 2 diabetes (T2D). While conventional therapies primarily target epicardial coronary disease, effective treatments for CMD remain limited. Glucagon-like peptide-1 receptor (GLP-1R) agonists have emerged promising agents benefits extending beyond glycemic control. Preclinical clinical evidence suggests that GLP-1R activation enhances function through mechanisms including improved endothelial function, increased nitric oxide bioavailability, attenuation of oxidative stress, reduced vascular inflammation. Moreover, been shown improve blood flow, perfusion reserve, high-risk populations. Despite these findings, inconsistencies across studies due variability patient populations, study designs, imaging methodologies. This review summarizes current on the role perfusion, bridging mechanistic insights outcomes. Further large-scale, well-designed trials are needed clarify their long-term impact microcirculation explore potential targeted CMD.

Language: Английский

Citations

0
L-Arginine and Immune Modulation: A Pharmacological Perspective on Inflammation and Autoimmune Disorders DOI
Igbayilola Yusuff Dimeji,

Kasim Sakran Abass,

Ngabea Murtala Audu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177615 - 177615

Published: April 1, 2025

Language: Английский

Citations

0
DjCapon Affects the Neural Regeneration and Light Sensitivity via NO and Wnt5a Signaling in Planarian Dugesia japonica DOI
Wenshuo Xie,

Jicheng Qu,

Nianhong Xing

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0