Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma DOI Creative Commons

Manman Yao,

Ying-Chun Lu,

Tiejun Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 16, 2025

Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response modulation. This study aims explore the role of lipid metabolism, particularly lipids diacylglycerol (DAG), triacylglycerol (TAG), phosphatidylcholine (PC), progression from OLP OSCC, identify potential therapeutic targets for prevention treatment. We performed Mendelian randomization (MR) analysis investigate causal relationships between risk OSCC. Differential gene expression was conducted key genes related metabolism. The interactions species were examined using drug databases (DrugBank, DGIdb, TCMSP) candidates. Enrichment signaling pathways, including PPAR signaling, also understand underlying mechanisms. Our MR revealed DAG exerts protective effect (OR < 1), but its shifts factor OSCC > potentially by altering microenvironment. TAG PI plays critical tumorigenesis. Gene identified several metabolism-related genes, SLC27A6, FABP3, FABP4, ADIPOQ, PLIN1, whose differed highlighting their importance progression. These enriched pathway, suggesting involvement growth Potential candidates, such as palm acid (PA), Imatinib, Curcumin, through drug-repurposing strategies. crucial Targeting pathways DAG, TAG, PI, offer promising strategies early diagnosis intervention. provides novel insights into molecular mechanisms OLP-to-OSCC suggests natural compounds, future clinical applications. Further research needed validate these findings settings. Not applicable.

Language: Английский

Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma DOI Creative Commons

Manman Yao,

Ying-Chun Lu,

Tiejun Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 16, 2025

Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response modulation. This study aims explore the role of lipid metabolism, particularly lipids diacylglycerol (DAG), triacylglycerol (TAG), phosphatidylcholine (PC), progression from OLP OSCC, identify potential therapeutic targets for prevention treatment. We performed Mendelian randomization (MR) analysis investigate causal relationships between risk OSCC. Differential gene expression was conducted key genes related metabolism. The interactions species were examined using drug databases (DrugBank, DGIdb, TCMSP) candidates. Enrichment signaling pathways, including PPAR signaling, also understand underlying mechanisms. Our MR revealed DAG exerts protective effect (OR < 1), but its shifts factor OSCC > potentially by altering microenvironment. TAG PI plays critical tumorigenesis. Gene identified several metabolism-related genes, SLC27A6, FABP3, FABP4, ADIPOQ, PLIN1, whose differed highlighting their importance progression. These enriched pathway, suggesting involvement growth Potential candidates, such as palm acid (PA), Imatinib, Curcumin, through drug-repurposing strategies. crucial Targeting pathways DAG, TAG, PI, offer promising strategies early diagnosis intervention. provides novel insights into molecular mechanisms OLP-to-OSCC suggests natural compounds, future clinical applications. Further research needed validate these findings settings. Not applicable.

Language: Английский

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