Obesity and acylcarnitine derivates interplay with coronary artery disease DOI Creative Commons
Tomasz Urbanowicz,

Paweł Gutaj,

Szymon Plewa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular associated abnormal levels acylated derivates carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary disease, including obese individuals. Twenty consecutive presenting dyspnea on exertion were enrolled prospective analysis for metabolomic profiling. They divided into two groups regarding CAD presence. Six (60%) men four (40%) women comprised group assigned as Group 1, while 6 4 normal arteries angiograms 2. Compared non-CAD group, was characterized by lower sum long-chain ACs (p = 0.024), short-chain 0.022), saturated fatty acids (SFA) 0.030) monounsaturated (MUFA) 0.022). Further subanalysis concerning patients' body mass index showed significant differences plasma 0.050) SFA but not 0.060), medium-ACs 0.758), long-chain-ACs 0.141), or MUFA 0.151). Our revealed acylcarnitine CAD.

Language: Английский

Obesity and acylcarnitine derivates interplay with coronary artery disease DOI Creative Commons
Tomasz Urbanowicz,

Paweł Gutaj,

Szymon Plewa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular associated abnormal levels acylated derivates carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary disease, including obese individuals. Twenty consecutive presenting dyspnea on exertion were enrolled prospective analysis for metabolomic profiling. They divided into two groups regarding CAD presence. Six (60%) men four (40%) women comprised group assigned as Group 1, while 6 4 normal arteries angiograms 2. Compared non-CAD group, was characterized by lower sum long-chain ACs (p = 0.024), short-chain 0.022), saturated fatty acids (SFA) 0.030) monounsaturated (MUFA) 0.022). Further subanalysis concerning patients' body mass index showed significant differences plasma 0.050) SFA but not 0.060), medium-ACs 0.758), long-chain-ACs 0.141), or MUFA 0.151). Our revealed acylcarnitine CAD.

Language: Английский

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