Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles DOI Creative Commons
Yuan Zou, Jing Zhang, Longmin Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 388 - 388

Published: March 18, 2025

Neuroinflammation within the central nervous system (CNS) is a primary characteristic of CNS diseases, such as Parkinson’s disease, Alzheimer’s disease (AD), amyotrophic lateral sclerosis, and mental disorders. The excessive activation immune cells results in massive release pro-inflammatory cytokines, which subsequently induce neuronal death accelerate progression neurodegeneration. Therefore, mitigating neuroinflammation has emerged promising strategy for treatment diseases. Despite advancements drug discovery development novel therapeutics, effective delivery these agents to remains serious challenge due restrictive nature blood–brain barrier (BBB). This underscores need develop system. Recent studies have identified oral lipid nanoparticles (LNPs) approach efficiently deliver drugs across BBB treat neurological review aims comprehensively summarize recent LNPs designed controlled therapeutic modulation diseases through administration. Furthermore, this addresses mechanisms by overcome biological barriers evaluate their clinical implications efficacy context systems. Specifically, it focuses on LNP formulations that facilitate administration, exploring potential enhance bioavailability, improve targeting precision, alleviate or manage symptoms associated with range

Language: Английский

Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review DOI Creative Commons

Andreea Sălcudean,

Cristina-Raluca Bodo,

Ramona Amina Popovici

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 502 - 502

Published: March 30, 2025

Depression is a multifactorial psychiatric condition with complex pathophysiology, increasingly linked to neuroinflammatory processes. The present review explores the role of neuroinflammation in depression, focusing on glial cell activation, cytokine signaling, blood-brain barrier dysfunction, and disruptions neurotransmitter systems. article highlights how inflammatory mediators influence brain regions implicated mood regulation, such as hippocampus, amygdala, prefrontal cortex. further discusses involvement hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, kynurenine pathway, providing mechanistic insights into chronic inflammation may underlie emotional cognitive symptoms depression. bidirectional relationship between depressive emphasized, along peripheral immune responses systemic stress. By integrating molecular, cellular, neuroendocrine perspectives, this supports growing field immunopsychiatry lays foundation for novel diagnostic biomarkers anti-inflammatory treatment approaches Further research holds promise developing more effective personalized interventions individuals suffering from

Language: Английский

Citations

0
Dietary Habits and Their Influence on the Microbiome and Mental Health in Adolescents DOI Open Access

Andreea Sălcudean,

Dora-Mihaela Cîmpian,

Ramona Amina Popovici

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1496 - 1496

Published: April 29, 2025

Adolescence represents a critical developmental stage where diet, gut microorganisms, and mental health are strongly interconnected. The current literature evidences the bidirectional role between dietary habits psychological well-being, which is mediated by gut-brain axis. purpose of this review to highlight importance in adolescence period impact different food choices on microbiota secondary health. Gut plays vital synthesis neurotransmitters such as serotonin, dopamine, noradrenaline, metabolites like short-chain fatty acids (SCFAs). disruption composition called dysbiosis, has been associated with systemic inflammation state chronic stress. They contribute onset psychiatric disorders including MDD, anxiety, ADHD, autism. Diets high quantity sugar low fiber alteration poor Additionally, early-life stress, antibiotic usage, may alter bacterial communities, long-term implications for adolescents Dietary interventions, intake prebiotics, probiotics, SCFAs, micronutrients could restore microbial balance improve symptoms. This highlights diet adolescent emphasizes need integrative strategies promote resilience through microbiome regulation.

Language: Английский

Citations

0
Physical exercise ameliorates pain, mood alterations and neuroinflammation in a murine model of osteoarthritis DOI Creative Commons
Giada Amodeo, Giulia Galimberti, Stefania Ceruti

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123710 - 123710

Published: May 1, 2025

Language: Английский

Citations

0
Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles DOI Creative Commons
Yuan Zou, Jing Zhang, Longmin Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 388 - 388

Published: March 18, 2025

Neuroinflammation within the central nervous system (CNS) is a primary characteristic of CNS diseases, such as Parkinson’s disease, Alzheimer’s disease (AD), amyotrophic lateral sclerosis, and mental disorders. The excessive activation immune cells results in massive release pro-inflammatory cytokines, which subsequently induce neuronal death accelerate progression neurodegeneration. Therefore, mitigating neuroinflammation has emerged promising strategy for treatment diseases. Despite advancements drug discovery development novel therapeutics, effective delivery these agents to remains serious challenge due restrictive nature blood–brain barrier (BBB). This underscores need develop system. Recent studies have identified oral lipid nanoparticles (LNPs) approach efficiently deliver drugs across BBB treat neurological review aims comprehensively summarize recent LNPs designed controlled therapeutic modulation diseases through administration. Furthermore, this addresses mechanisms by overcome biological barriers evaluate their clinical implications efficacy context systems. Specifically, it focuses on LNP formulations that facilitate administration, exploring potential enhance bioavailability, improve targeting precision, alleviate or manage symptoms associated with range

Language: Английский

Citations

0