The Non-High-Density Lipoprotein Cholesterol (Non-HDL-C) to HDL-C Ratio (NHHR) and Its Association with Chronic Kidney Disease in Chinese Adults with Type 2 Diabetes: A Preliminary Study DOI Open Access
Xiangyu Chen,

Mingbin Liang,

Jie Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1125 - 1125

Published: March 24, 2025

Objectives: The objective of this study was to examine the association between non-high-density lipoprotein cholesterol (non-HDL-C) high-density (HDL-C) ratio (NHHR) and chronic kidney disease (CKD) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods: This originated from a survey carried out Zhejiang Province, located eastern China, March November 2018. To explore relationship NHHR CKD, multivariable logistic regression model employed. dose-response assessed using restricted cubic spline (RCS) analysis, while generalized additive models (GAMs) were applied associations urinary albumin-to-creatinine (UACR) as well estimated glomerular filtration rate (eGFR). Subgroup analyses performed across various demographic clinical categories assess consistency NHHR-CKD association. optimal cutoff for CKD diagnosis, its predictive accuracy, comparison components HbA1c determined through receiver operating characteristic (ROC) curve analysis. Results: enrolled 1756 participants, including 485 individuals 1271 without CKD. Multivariable revealed significant positive each standard deviation (SD) increase linked 23% higher odds (OR = 1.23, 95% CI: 1.09-1.37) after adjusting potential confounders. When comparing quartiles, fully adjusted ORs Q2, Q3, Q4 1.29 (0.92-1.79), 1.31 (0.94-1.83), 1.87 (1.34-2.60), respectively, relative Q1 (p trend < 0.01). RCS analysis confirmed linear both sexes nonlinearity > 0.05). GAMs indicated correlation UACR (ρ 0.109, p 0.001) but no eGFR -0.016, 0.502). demonstrated consistent most subgroups, except 18-44 years age group, well-controlled glycemic non-alcohol drinking group ROC identified an 3.48 prediction, area under (AUC) 0.606 (95% 0.577-0.635). Notably, outperformed individual performance. Conclusions: link levels increased prevalence T2DM patients. may also serve complementary biomarker early detection, though further prospective studies are needed confirm value utility high-risk populations.

Language: Английский

The Non-High-Density Lipoprotein Cholesterol (Non-HDL-C) to HDL-C Ratio (NHHR) and Its Association with Chronic Kidney Disease in Chinese Adults with Type 2 Diabetes: A Preliminary Study DOI Open Access
Xiangyu Chen,

Mingbin Liang,

Jie Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1125 - 1125

Published: March 24, 2025

Objectives: The objective of this study was to examine the association between non-high-density lipoprotein cholesterol (non-HDL-C) high-density (HDL-C) ratio (NHHR) and chronic kidney disease (CKD) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods: This originated from a survey carried out Zhejiang Province, located eastern China, March November 2018. To explore relationship NHHR CKD, multivariable logistic regression model employed. dose-response assessed using restricted cubic spline (RCS) analysis, while generalized additive models (GAMs) were applied associations urinary albumin-to-creatinine (UACR) as well estimated glomerular filtration rate (eGFR). Subgroup analyses performed across various demographic clinical categories assess consistency NHHR-CKD association. optimal cutoff for CKD diagnosis, its predictive accuracy, comparison components HbA1c determined through receiver operating characteristic (ROC) curve analysis. Results: enrolled 1756 participants, including 485 individuals 1271 without CKD. Multivariable revealed significant positive each standard deviation (SD) increase linked 23% higher odds (OR = 1.23, 95% CI: 1.09-1.37) after adjusting potential confounders. When comparing quartiles, fully adjusted ORs Q2, Q3, Q4 1.29 (0.92-1.79), 1.31 (0.94-1.83), 1.87 (1.34-2.60), respectively, relative Q1 (p trend < 0.01). RCS analysis confirmed linear both sexes nonlinearity > 0.05). GAMs indicated correlation UACR (ρ 0.109, p 0.001) but no eGFR -0.016, 0.502). demonstrated consistent most subgroups, except 18-44 years age group, well-controlled glycemic non-alcohol drinking group ROC identified an 3.48 prediction, area under (AUC) 0.606 (95% 0.577-0.635). Notably, outperformed individual performance. Conclusions: link levels increased prevalence T2DM patients. may also serve complementary biomarker early detection, though further prospective studies are needed confirm value utility high-risk populations.

Language: Английский

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