The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases DOI Open Access

Waleria Wolska,

Izabela Gutowska, Agata Wszołek

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4742 - 4742

Published: May 15, 2025

Intermittent fasting (IF) is a dietary approach that influences key metabolic pathways, including autophagy-a crucial mechanism in maintaining cellular homeostasis. Autophagy plays dual role oncogenesis, acting both as tumor suppressor and survival under stress. IF has shown potential for reducing cancer risk enhancing therapeutic efficacy by sensitizing cells to chemotherapy radiotherapy. However, its effects depend heavily on the type stage of cancer. Potential risks, such excessive weight loss malnutrition, require careful evaluation. Further clinical studies are needed optimize protocols adjuncts therapy. This review discusses autophagy mechanisms induced IF, their implications oncology, limitations this strategy.

Language: Английский

The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases DOI Open Access

Waleria Wolska,

Izabela Gutowska, Agata Wszołek

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4742 - 4742

Published: May 15, 2025

Intermittent fasting (IF) is a dietary approach that influences key metabolic pathways, including autophagy-a crucial mechanism in maintaining cellular homeostasis. Autophagy plays dual role oncogenesis, acting both as tumor suppressor and survival under stress. IF has shown potential for reducing cancer risk enhancing therapeutic efficacy by sensitizing cells to chemotherapy radiotherapy. However, its effects depend heavily on the type stage of cancer. Potential risks, such excessive weight loss malnutrition, require careful evaluation. Further clinical studies are needed optimize protocols adjuncts therapy. This review discusses autophagy mechanisms induced IF, their implications oncology, limitations this strategy.

Language: Английский

Citations

0