Role of Mitochondrial Dysfunction in UV‐Induced Photoaging and Skin Cancers

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(5)

Published: May 1, 2025

ABSTRACT Ultraviolet radiation (UVR) is the most detrimental external factor that induces acute photodamage, photoaging and skin cancers, with complex underlying molecular mechanisms initiated mainly by increased DNA damage reactive oxygen species (ROS) generation. Mitochondria are main organelles in cells produce ROS energy regulate various physiological pathological signalling pathways. Continuous UVR on human can induce mitochondrial mutations excessive production, creating feedback between each other subsequently causing a reduction membrane potential (MMP) respiratory capacity. Deficiencies function apoptosis, mitophagy senescence, resulting UVR‐induced photodamage photoaging. Mitochondrial biogenesis metabolic pathways play critical roles progression of particularly melanoma, which malignant infrequent type cancer. In this review, we describe recent advances determining intimate relationship damage, suggesting candidates novel chemical/natural components to protect from cancers via targeting mechanisms.

Language: Английский

Functional Features of Senescent Cells and Implications for Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5390 - 5390

Published: June 4, 2025

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function tissues and organs, significantly contributimg to aging organism. Functional structural characteristics senescent cells, such as genomic changes cell cycle arrest, lysosome mitochondrial dysfunction, production SASP factors, are promising therapeutic targets in context healthy longevity. The present review was designed characterize features order discuss current methods problems geroprotective therapy perspective factors for development new strategies anti-aging treatment. Publications were searched based on analysis articles containing keywords “senescent aging, senolytic therapy, SASP, dysfunction” PubMed Scopus databases up March 2025.

Language: Английский