Role of Mitochondrial Dysfunction in UV‐Induced Photoaging and Skin Cancers
Xinghua Yuan,
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Huixin Li,
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Ji Su Lee
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et al.
Experimental Dermatology,
Journal Year:
2025,
Volume and Issue:
34(5)
Published: May 1, 2025
ABSTRACT
Ultraviolet
radiation
(UVR)
is
the
most
detrimental
external
factor
that
induces
acute
photodamage,
photoaging
and
skin
cancers,
with
complex
underlying
molecular
mechanisms
initiated
mainly
by
increased
DNA
damage
reactive
oxygen
species
(ROS)
generation.
Mitochondria
are
main
organelles
in
cells
produce
ROS
energy
regulate
various
physiological
pathological
signalling
pathways.
Continuous
UVR
on
human
can
induce
mitochondrial
mutations
excessive
production,
creating
feedback
between
each
other
subsequently
causing
a
reduction
membrane
potential
(MMP)
respiratory
capacity.
Deficiencies
function
apoptosis,
mitophagy
senescence,
resulting
UVR‐induced
photodamage
photoaging.
Mitochondrial
biogenesis
metabolic
pathways
play
critical
roles
progression
of
particularly
melanoma,
which
malignant
infrequent
type
cancer.
In
this
review,
we
describe
recent
advances
determining
intimate
relationship
damage,
suggesting
candidates
novel
chemical/natural
components
to
protect
from
cancers
via
targeting
mechanisms.
Language: Английский
Functional Features of Senescent Cells and Implications for Therapy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(11), P. 5390 - 5390
Published: June 4, 2025
Cellular
senescence
is
a
key
mechanism
of
aging.
Senescent
cells
negatively
affect
the
function
tissues
and
organs,
significantly
contributimg
to
aging
organism.
Functional
structural
characteristics
senescent
cells,
such
as
genomic
changes
cell
cycle
arrest,
lysosome
mitochondrial
dysfunction,
production
SASP
factors,
are
promising
therapeutic
targets
in
context
healthy
longevity.
The
present
review
was
designed
characterize
features
order
discuss
current
methods
problems
geroprotective
therapy
perspective
factors
for
development
new
strategies
anti-aging
treatment.
Publications
were
searched
based
on
analysis
articles
containing
keywords
“senescent
aging,
senolytic
therapy,
SASP,
dysfunction”
PubMed
Scopus
databases
up
March
2025.
Language: Английский