Mas Receptor as a Target for Neuropathic Pain Management: Insights into Angiotensin-(1-7) Signaling and Therapeutic Opportunities DOI

Surekha A. Devi,

Saajan Kumar Sharma,

Sandip Tejpal

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(2), P. 167 - 176

Published: April 30, 2025

Mas is a G protein-coupled receptor (GPCR) that binds to Angiotensin (1-7) and it evaluated as an important element of non classical Renin System. While the RAS axis has been considered pro-inflammatory pro-nociceptive by leveraging II AT1 receptor, /Mas offers anti-inflammatory, vessels dilating, neuroprotective functions. It produced two mechanisms first, obtained from via mechanism angiotensin converting enzyme 2 (ACE2) also binding formed Ang-(1-7) its activates several signaling pathways such PI3K/Akt, ERK1/2 nitric oxide (NO). These together prevent neuronal death, decrease oxidative stress inhibit nuclear factor-kappa B (NF-κB), reduces expression various cytokines like TNF-α, IL-1β IL-6. With regard neuropathic pain, contributes regulation glial-neuronal crosstalk negative microglial astrocytic activity neuroimmune balance. Experimental studies have shown use or synthetic activators attenuates mechanical alodynia thermal hypoesthesia, proving Marques colleagues’ hypothesis possible therapeutic applications. Also, functional cross-talk with other pain-modulatory systems, including endogenous opioid endocannabinoid contributing enhancer this sort analgesia. Thus, novel (1-7)/Mas pathway can be promising candidate for new non-opioid analgesic treatment pain. Further research in agonists, peptide analogs, targeted drug delivery system shows there potential practical application these discoveries.

Language: Английский

Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review DOI Open Access

Giorgia Cominelli,

Francesca Sulas,

Daniela Pinto

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1502 - 1502

Published: April 29, 2025

Pain is a significant global public health issue that can interfere with daily activities, sleep, and interpersonal relationships when it becomes chronic or worsens, ultimately impairing quality of life. Despite ongoing efforts, the efficacy pain treatments in improving outcomes for patients remains limited. At present, challenge lies developing personalized care management plan helps to maintain patient activity levels effectively manages pain. Neuropathic condition resulting from damage somatosensory nervous system, significantly impacting It partly thought be caused by inflammation oxidative stress, clinical research has suggested link between this diet. However, these links are not yet well understood require further investigation evaluate pathways involved neuropathic Specifically, question whether supplementation dietary antioxidants, such as melatonin, could serve potential adjunctive treatment modulation. Melatonin, primarily secreted pineal gland but also produced other systems digestive known its anti-inflammatory, antioxidant, anti-aging properties. found various fruits vegetables, presence alongside polyphenols foods may enhance melatonin intake contribute improved health. The aim review provide an overview examine role neuro-nutritional approach management.

Language: Английский

Citations

0
Mas Receptor as a Target for Neuropathic Pain Management: Insights into Angiotensin-(1-7) Signaling and Therapeutic Opportunities DOI

Surekha A. Devi,

Saajan Kumar Sharma,

Sandip Tejpal

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(2), P. 167 - 176

Published: April 30, 2025

Mas is a G protein-coupled receptor (GPCR) that binds to Angiotensin (1-7) and it evaluated as an important element of non classical Renin System. While the RAS axis has been considered pro-inflammatory pro-nociceptive by leveraging II AT1 receptor, /Mas offers anti-inflammatory, vessels dilating, neuroprotective functions. It produced two mechanisms first, obtained from via mechanism angiotensin converting enzyme 2 (ACE2) also binding formed Ang-(1-7) its activates several signaling pathways such PI3K/Akt, ERK1/2 nitric oxide (NO). These together prevent neuronal death, decrease oxidative stress inhibit nuclear factor-kappa B (NF-κB), reduces expression various cytokines like TNF-α, IL-1β IL-6. With regard neuropathic pain, contributes regulation glial-neuronal crosstalk negative microglial astrocytic activity neuroimmune balance. Experimental studies have shown use or synthetic activators attenuates mechanical alodynia thermal hypoesthesia, proving Marques colleagues’ hypothesis possible therapeutic applications. Also, functional cross-talk with other pain-modulatory systems, including endogenous opioid endocannabinoid contributing enhancer this sort analgesia. Thus, novel (1-7)/Mas pathway can be promising candidate for new non-opioid analgesic treatment pain. Further research in agonists, peptide analogs, targeted drug delivery system shows there potential practical application these discoveries.

Language: Английский

Citations

0