The Use of Hyaluronic Acid in the Non-Surgical Treatment of Periodontitis—An Umbrella Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 998 - 998

Published: April 20, 2025

Background: Periodontitis is a prevalent inflammatory condition that destroys periodontal tissues. Scaling and root planing (SRP) the gold standard for non-surgical treatment; however, its efficacy may be limited in cases with complex dental issues. This umbrella review aims to evaluate effectiveness of hyaluronic acid (HA) as an adjunct scaling enhancing clinical outcomes periodontitis management. Methods: A comprehensive five systematic reviews, including meta-analyses where available, was conducted synthesize evidence on adjunctive use HA SRP. The studies were evaluated using AMSTAR-2 quality assessment tool determine methodological rigor. Data parameters such probing depth (PD), attachment level (CAL), bleeding (BOP), gingival index (GI), plaque (PI) extracted analyzed. Results: findings indicate supplementation leads moderate improvements PD, CAL, BOP, GI, PI compared SRP alone. Notable reductions PD gains CAL observed, some showing statistically significant benefits. However, heterogeneity concentrations (0.2–1.4%), application methods, treatment frequencies, follow-up durations (1 week 12 months) limits definitive conclusions. Additionally, did not significantly affect reduction P. gingivalis prevalence. Conclusions: conjunction shows promise therapy. methodologies indicates necessity high-quality, standardized randomized controlled trials establish clear guidelines periodontitis.

Language: Английский

Comparative Evaluation of Platelet-Rich Fibrin (PRF) and Concentrated Growth Factor (CGF) as Carriers for Antibiotics—In Vitro Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4303 - 4303

Published: May 1, 2025

The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase growth factors (LPCGFs), have emerged as potential carriers antimicrobial agents. This study aimed to evaluate efficacy c-PRF LPCGF three formulations-amoxicillin with clavulanic acid, clindamycin, a combination amoxicillin metronidazole-against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant (MRSA), Enterococcus faecalis (low-level natural resistance). disk diffusion method was employed incorporate antibiotics into both APC types, which were then applied disks placed on bacterial cultures. size inhibition zones measured at 20-, 40-, 60-, 80-h intervals. Every 20 h, transferred new Petri dish. Statistical analysis included Welch's t-test two-way ANOVA. demonstrated superior performance carrier showing presence up 60 h. In contrast, exhibited greater when used amoxicillin-metronidazole combination, particularly higher concentrations. Both APCs showed limited effectiveness against E. combined clindamycin. confirms suitability autologous systems. choice between should be guided by drug's physicochemical properties clinical application. offer promising alternative targeted therapy in dental surgical settings.

Language: Английский

PRF and PRP in Dentistry: An Umbrella Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3224 - 3224

Published: May 6, 2025

Introduction: Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) utilize autologous blood share the objective of leveraging blood-derived growth factors to enhance body’s natural healing process. A large extensive use has been made in various branches dentistry. Methods: total 4175 records were identified from electronic search, specifically 291 BioMed Central, 3406 MEDLINE/PubMed, 304 Cochrane library databases, 174 PROSPERO register. This review was performed relation PRISMA flow chart annotated Results: In total, 3416 title abstracts screened, a 40 systematic reviews finally included present umbrella review. Conclusions: Research supports PRF PRP different fields is huge potential for patient but also doctor as these products are have zero cost. However, further studies needed, especially RCTs, clearer evidence on role PRP.

Language: Английский