Sex differences in the sensitization of prenatally programmed hypertension DOI Creative Commons
Baojian Xue, Alan Kim Johnson, Alexander G. Bassuk

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Studies have demonstrated that there are sex differences in the timing of onset and severity prenatally programmed hypertension, with consistently milder phenotypes observed females relative to male offspring. However, root cause(s) for these sex-specific effects is unknown. Activation renin-angiotensin system (RAS), elevated oxidative stress inflammation, sympathetic hyperactivity cardiovascular organs regulatory systems, all involved pathogenesis hypertension. Sex hormones interact prohypertensive systems modulate blood pressure, this interaction may lead a development A more complete understanding functional capabilities their interactions factors offspring, from early life aging, would likely new insights into basis Recently, we discovered also occur sensitization offspring hypertension as by maternal gestational requires brain RAS proinflammatory factors. In review, will discuss possible mechanisms underlying mothers exposed various prenatal insults. These operate at levels periphery central nervous (e.g., vessel, heart, kidney, brain). Understanding responsible sensitized state can help develop therapeutic strategies interrupting vicious cycle transgenerational treating men women differentially maximize efficacy.

Language: Английский

Sex differences in the sensitization of prenatally programmed hypertension DOI Creative Commons
Baojian Xue, Alan Kim Johnson, Alexander G. Bassuk

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Studies have demonstrated that there are sex differences in the timing of onset and severity prenatally programmed hypertension, with consistently milder phenotypes observed females relative to male offspring. However, root cause(s) for these sex-specific effects is unknown. Activation renin-angiotensin system (RAS), elevated oxidative stress inflammation, sympathetic hyperactivity cardiovascular organs regulatory systems, all involved pathogenesis hypertension. Sex hormones interact prohypertensive systems modulate blood pressure, this interaction may lead a development A more complete understanding functional capabilities their interactions factors offspring, from early life aging, would likely new insights into basis Recently, we discovered also occur sensitization offspring hypertension as by maternal gestational requires brain RAS proinflammatory factors. In review, will discuss possible mechanisms underlying mothers exposed various prenatal insults. These operate at levels periphery central nervous (e.g., vessel, heart, kidney, brain). Understanding responsible sensitized state can help develop therapeutic strategies interrupting vicious cycle transgenerational treating men women differentially maximize efficacy.

Language: Английский

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