Basic mechanism of mobilizing cell movement during invasion of glioblastoma and target selection of targeted therapy DOI Creative Commons
Jie Xu, Pengfei Shi, Liqun Yang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Glioblastoma (GBM), also known as glioblastoma multiforme, is a rapidly growing and highly invasive malignant tumor. Due to the inability clearly distinguish between normal tissue, surgery cannot achieve safe resection, often leading poor patient prognosis inevitable tumor recurrence. According previous studies, GBM invasion related intercellular adhesion, matrix degradation, extracellular its adhesion molecules, well molecular of protein hydrolases in microenvironment cells stromal cells. The aim enhance our understanding mechanisms underlying advance research on targeted therapies for inhibiting invasion. This article describes that may affect cell invasion, changes cytoskeleton during motility, regulatory intracellular signaling pathways In addition, we explored possibility therapy against molecules GBM.

Language: Английский

Basic mechanism of mobilizing cell movement during invasion of glioblastoma and target selection of targeted therapy DOI Creative Commons
Jie Xu, Pengfei Shi, Liqun Yang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Glioblastoma (GBM), also known as glioblastoma multiforme, is a rapidly growing and highly invasive malignant tumor. Due to the inability clearly distinguish between normal tissue, surgery cannot achieve safe resection, often leading poor patient prognosis inevitable tumor recurrence. According previous studies, GBM invasion related intercellular adhesion, matrix degradation, extracellular its adhesion molecules, well molecular of protein hydrolases in microenvironment cells stromal cells. The aim enhance our understanding mechanisms underlying advance research on targeted therapies for inhibiting invasion. This article describes that may affect cell invasion, changes cytoskeleton during motility, regulatory intracellular signaling pathways In addition, we explored possibility therapy against molecules GBM.

Language: Английский

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