Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration
Foods,
Journal Year:
2025,
Volume and Issue:
14(9), P. 1559 - 1559
Published: April 29, 2025
Neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
the
most
common
form
of
dementia,
represent
a
growing
global
health
crisis,
yet
current
treatment
strategies
remain
primarily
palliative.
Recent
studies
have
shown
that
neurodegeneration
through
complex
interactions
within
gut-brain
axis
largely
depends
on
gut
microbiota
and
its
metabolites.
This
review
explores
intricate
molecular
mechanisms
linking
dysbiosis
to
cognitive
decline,
emphasizing
impact
microbial
metabolites,
including
short-chain
fatty
acids
(SCFAs),
bile
acids,
tryptophan
neuroinflammation,
blood-brain
barrier
(BBB)
integrity,
amyloid-β
tau
pathology.
The
paper
highlights
major
microbiome
signatures
associated
with
disease,
detailing
their
metabolic
pathways
inflammatory
crosstalk.
Dietary
interventions
promise
in
modulating
composition,
potentially
mitigating
neurodegenerative
processes.
critically
examines
influence
dietary
patterns,
Mediterranean
Western
diets,
microbiota-mediated
neuroprotection.
Bioactive
compounds
like
prebiotics,
omega-3
polyphenols
exhibit
neuroprotective
effects
by
reducing
neuroinflammation.
Furthermore,
it
discusses
emerging
microbiome-based
therapeutic
strategies,
probiotics,
postbiotics,
fecal
transplantation
(FMT),
potential
for
slowing
progression.
Despite
these
advances,
several
knowledge
gaps
remain,
interindividual
variability
responses
need
large-scale,
longitudinal
studies.
study
proposes
an
integrative,
precision
medicine
approach,
incorporating
science
into
paradigms.
Ultimately,
cognizance
at
mechanistic
level
could
unlock
novel
avenues,
offering
non-invasive,
diet-based
strategy
managing
improving
health.
Language: Английский
Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 12, 2025
Diquat
is
a
widely
used
bipyridyl
herbicide
that
extensively
applied
in
agricultural
production
and
water
management
due
to
its
high
efficacy
weed
control.
However,
environmental
persistence
the
toxic
effects
it
induces
have
raised
widespread
concern.
Studies
show
primarily
enters
body
through
digestive
tract,
leading
poisoning.
The
core
mechanism
of
toxicity
involves
reactive
oxygen
species
(ROS)-induced
oxidative
stress,
which
not
only
directly
damages
intestinal
barrier
function
but
also
exacerbates
inflammation
systemic
by
disrupting
balance
gut
microbiota
normal
metabolic
products.
This
review
systematically
summarizes
physicochemical
properties
Diquat,
with
focus
on
analyzing
mechanisms
tissue
structure,
function,
after
tract
exposure.
aim
provide
theoretical
support
for
deeper
understanding
Diquat's
tract-centered
characteristics,
laying
scientific
foundation
development
effective
interventions
protective
strategies
against
toxicity.
Language: Английский
Bacterial Extracellular Vesicles in Oncology: Molecular Mechanisms and Future Clinical Applications
Cancers,
Journal Year:
2025,
Volume and Issue:
17(11), P. 1774 - 1774
Published: May 26, 2025
Bacterial
extracellular
vesicles
(BEVs)
have
emerged
as
pivotal
mediators
of
host–microbe
interactions,
profoundly
influencing
cancer
biology.
These
nanoscale
vesicles,
produced
by
both
Gram-positive
and
Gram-negative
bacteria,
carry
diverse
biomolecular
cargo
such
proteins,
lipids,
nucleic
acids,
metabolites.
BEVs
play
dualistic
roles
in
tumor
promotion
suppression
modulating
the
microenvironment,
immune
responses,
genetic
regulation.
This
review
synthesizes
current
understanding
various
cancers,
including
gastrointestinal,
ovarian,
breast,
lung,
brain,
renal
malignancies.
are
highlighted
for
their
potential
diagnostic
biomarkers,
prognostic
indicators,
therapeutic
agents,
applications
immunotherapy
advanced
engineering
precision
medicine.
Challenges
heterogeneity,
standardization,
clinical
scalability
critically
analyzed,
with
case
examples
providing
actionable
insights.
Future
directions
emphasize
interdisciplinary
collaborations,
emerging
technologies,
integration
BEV-based
tools
into
workflows.
underscores
transformative
advancing
diagnostics
therapeutics,
paving
way
innovations
oncology.
Language: Английский