Immunotherapeutic Approaches to Peanut Allergy Treatment—Pre-Clinical and Clinical Studies: A Comprehensive Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1902 - 1902

Published: March 12, 2025

Peanut allergy is a prevalent and potentially life-threatening condition affecting millions of people worldwide, necessitating strict dietary vigilance. Despite its widespread impact, current treatment options are predominantly limited to allergen avoidance emergency management allergic reactions. This review explores contemporary immunotherapeutic strategies aimed at achieving long-term relief for individuals with peanut allergy. We conducted comprehensive literature discuss different approaches, such as subcutaneous immunotherapy (SCIT), epicutaneous (EPIT), oral (OIT), sublingual (SLIT), focusing on their mechanisms, efficacy, safety profiles. Additionally, the delves into novel approaches monoclonal antibodies targeting IgE other critical immune pathways, adjuvanted therapies utilizing nanoparticles gut microbiota, advances in adoptive cell therapy including CAR-T cells regulatory T cells. Furthermore, we highlight some clinical trials that test efficacy these patients Collectively, provide an overview advancements interventions recommendations personalized regimens, ultimately paving way more effective strategies.

Language: Английский

Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration

Human Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский