Citrus sinensis Seed-Mediated Gold Nanoparticles for Combating Diabetes and Bacterial Infections: A Promising Multifunctional Nano Formulation DOI
Zeeshan Rafi, Salman Khan, Subuhi Sherwani

et al.

Science of Advanced Materials, Journal Year: 2024, Volume and Issue: 16(2), P. 260 - 270

Published: Feb. 1, 2024

This investigation explores the successful synthesis and comprehensive characterization of Citrus sinensis seed-mediated gold nanoparticles designated as C-AuNPs. Visual confirmation was achieved through a distinct ruby red color change in reaction mixture, followed by UV-Visible spectroscopy, which revealed characteristic peak absorbance at 522 nm due to Surface Plasmon Resonance (SPR) phenomenon associated with nanoparticles. Transmission Electron Microscopy (TEM) analysis demonstrated uniform, spherical an average size 19 nm, ideal for biomedical applications. Dynamic Light Scattering (DLS) hydrodynamic 55 hydrated state, while negative zeta potential −17 mV indicated colloidal stability. C-AuNPs exhibited significant antibacterial activity against both Gram-negative Gram-positive bacterial strains, surpassing performance levofloxacin. Lower Minimum Inhibitory Concentration (MIC) values strains further supported their enhanced efficacy, potentially interactions cell membranes. Furthermore, potent inhibition α -amylase -glucosidase enzymes involved glucose metabolism, IC 50 comparable anti-diabetic drug acarbose. suggests agents, ability regulate blood sugar levels. exhibit unique optical, structural, electrostatic properties, making them promising candidates diverse Their small size, stability, properties position valuable assets realm nanomedicine therapeutics, warranting exploration development.

Language: Английский

Bringing Lab to the Field: Exploring Innovations in Point-of-Care Diagnostics for the Rapid Detection and Management of Tropical Diseases in Resource-Limited Settings DOI Creative Commons
Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola, Godfred Yawson Scott

et al.

Advances in Biomarker Sciences and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Citrus sinensis Seed-Mediated Gold Nanoparticles for Combating Diabetes and Bacterial Infections: A Promising Multifunctional Nano Formulation DOI
Zeeshan Rafi, Salman Khan, Subuhi Sherwani

et al.

Science of Advanced Materials, Journal Year: 2024, Volume and Issue: 16(2), P. 260 - 270

Published: Feb. 1, 2024

This investigation explores the successful synthesis and comprehensive characterization of Citrus sinensis seed-mediated gold nanoparticles designated as C-AuNPs. Visual confirmation was achieved through a distinct ruby red color change in reaction mixture, followed by UV-Visible spectroscopy, which revealed characteristic peak absorbance at 522 nm due to Surface Plasmon Resonance (SPR) phenomenon associated with nanoparticles. Transmission Electron Microscopy (TEM) analysis demonstrated uniform, spherical an average size 19 nm, ideal for biomedical applications. Dynamic Light Scattering (DLS) hydrodynamic 55 hydrated state, while negative zeta potential −17 mV indicated colloidal stability. C-AuNPs exhibited significant antibacterial activity against both Gram-negative Gram-positive bacterial strains, surpassing performance levofloxacin. Lower Minimum Inhibitory Concentration (MIC) values strains further supported their enhanced efficacy, potentially interactions cell membranes. Furthermore, potent inhibition α -amylase -glucosidase enzymes involved glucose metabolism, IC 50 comparable anti-diabetic drug acarbose. suggests agents, ability regulate blood sugar levels. exhibit unique optical, structural, electrostatic properties, making them promising candidates diverse Their small size, stability, properties position valuable assets realm nanomedicine therapeutics, warranting exploration development.

Language: Английский

Citations

0