Toxicological Implications of Platinum Group Elements (PGEs): A Systematic Review of In Vivo and In Vitro Studies Using Mammalian Models

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(8)

Published: Aug. 22, 2024

Background: The six Platinum group metal elements (PGEs) comprising Ruthenium, Rhodium, Palladium, Platinum, Iridium and Osmium are grouped together in the periodic table. Human activities mostly responsible for releasing PGEs into environment. This systematic review focused on three with greatest anthropogenic use, including vehicle catalytic converters: (Pt), Palladium (Pd), Rhodium (Rh). Consequently, these represent contributors to environmental pollution. current of vivo toxicological studies (mammalian models) vitro cell exposure examined potential harmful effects metalloids mammalians, their possible toxicity human health. Methods: We applied Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) methodology conduct a comprehensive search evaluation records available literature published between 01/01/2009 01/15/2024 four databases. PROSPERO code ID: CRD42024471558. Results concerning health were extracted from articles according inclusion exclusion criteria. After screening eligibility, 22 included final analysis. Results: revealed that airborne significantly increased activation pathologic pathways several organs and/or perturbed various metabolic pathways. In view known pro-inflammatory organ-degenerative PGEs, paucity effect central nervous system correlations neurodegenerative diseases particularly evident. Conclusions: clinical complexity chronic nature PGE-related pathologies indicate targeted research is essential. light increasing incidence non-communicable diseases, particular attention should be paid design epidemiological monitoring services.

Language: Английский

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Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 231, P. 116644 - 116644

Published: Nov. 20, 2024

Language: Английский

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KAJIAN KINETIKA ADSORPSI LOGAM TIMBAL (Pb) OLEH ADSORBEN PASIR TERAKTIVASI NAOH DENGAN VARIASI KONSENTRASI

Lantanida Journal, Journal Year: 2024, Volume and Issue: 12(1), P. 16 - 16

Published: June 8, 2024

This study analyzes the adsorption kinetics of highly toxic heavy metal Pb(II) using white sand adsorbent.The adsorbent was activated with NaOH at concentrations 2, 4, and 6 M. The method used in presence NaOH.The aim research to determine pattern.The employed this is batch varying time intervals 15, 30, 60, 90, 120 minutes.The uptake measured a linear regression equation.The behavior pattern by analyzed first-order second-order models, as well pseudo-first-order Lagergren equation pseudo-second-order Ho found that adsorbents, various variations both control M, followed pseudo coefficient determination (R 2 ) 1. Furthermore, values qe,exp qe,hit were be similar based on kinetics, being around 8.3 mg/g.The 4 M exhibits highest k value 206.921 g/mg.h,indicating faster rate adsorbate absorption.

Language: Английский

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Rational Design of Metal-Based Pharmacologically Active Compounds

Inorganics, Journal Year: 2024, Volume and Issue: 12(12), P. 335 - 335

Published: Dec. 22, 2024

Metal-based pharmacologically active compounds have been associated with many processes in vivo, acting as sites of metalloproteins [...]

Language: Английский

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