Platelet amino acid spectrum and gut microbiota, their links in patients with coronary artery disease and atrial fibrillation DOI Creative Commons

I.O. Melnychuk,

M.L. Sharayeva,

V.N. Kramarova

et al.

GASTROENTEROLOGY, Journal Year: 2023, Volume and Issue: 57(4), P. 227 - 233

Published: Dec. 22, 2023

Background. The aim of our work was to identify the links between platelet amino acid (AA) spectrum and gut microbiota composition in patients with coronary artery disease (CAD) atrial fibrillation (AF) evaluate them. Materials methods. Three hundred were enrolled study. They divided into 3 groups: I — 149 CAD but without arrhythmias, II (CAD + AF) 124 people AF paroxysm, control group (CG) 27 individuals arrhythmias. Platelet AA level assessed by method ion-exchange liquid column chromatography. Gut studied 16-S rRNA sequencing. Results. A significant increase isoleucine (10.73 %), leucine (12.63 %) a decrease threonine (23.05 serine (5.06 glycine (32.21 valine (30.83 platelets levels found (P < 0.05). In addition, they had Bacteroides spp., Faecalibacterium prausnitzii, Actinobacter Streptococcus Ruminococcus spp. Lactobacillus Bifidobacterium Eubacterium rectale glutamine acid, valine, glycine, asparagine highest number correlations species Blautia Akkermansia muciniphila Roseburia inulinivorans acids Conclusions. are closely linked.

Language: Английский

Inflammaging in Multidrug-Resistant Sepsis of Geriatric ICU Patients and Healthcare Challenges DOI Creative Commons
N. Kumar,

Tejashree A. Balraj,

Kusuma K Shivashankar

et al.

Geriatrics, Journal Year: 2024, Volume and Issue: 9(2), P. 45 - 45

Published: April 3, 2024

Multidrug-resistant sepsis (MDR) is a pressing concern in intensive care unit (ICU) settings, specifically among geriatric patients who experience age-related immune system changes and comorbidities. The aim of this review to explore the clinical impact MDR ICU shed light on healthcare challenges associated with its management. We conducted comprehensive literature search using National Center for Biotechnology Information (NCBI) Google Scholar engines. Our incorporated keywords such as "multidrug-resistant sepsis" OR "MDR sepsis", "geriatric patients" "elderly patients", "complications", "healthcare burdens", "diagnostic challenges", challenges" "ICU "geriatric/elderly patients". This explores specific risk factors contributing sepsis, complexities diagnostic challenges, burden faced by elderly patients. Notably, population bears higher (57.5%), influenced various factors, including comorbidities, immunosuppression, changes, resource-limited settings. Furthermore, imposes significant economic systems, annual costs exceeding $27 billion USA. These findings underscore urgency addressing need tailored interventions improve outcomes reduce costs.

Language: Английский

Citations

4
Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation DOI
X.J. Wang, Lei Huang, Min Hou

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

0
The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics DOI

Ashok Kumar Balaraman,

Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Circadian Rhythm, Hypoxia, and Cellular Senescence: From Molecular Mechanisms to Targeted Strategies DOI

Tong Nie,

Eugenie Nepovimová, Qinghua Wu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177290 - 177290

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cellular Senescence and Cardiovascular Aging DOI

Dharmesh Kapoor,

Imteyaz Qamar

Published: Jan. 1, 2025

Citations

0
Cellular senescence and senotherapeutics in cardiovascular diseases DOI

Arttatrana Pal

Advances in pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene DOI Creative Commons
Yijing Tao, Chengjie Gao, Juan Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318574 - e0318574

Published: March 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Language: Английский

Citations

0
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease DOI
Huimin Zheng, Tiantian Li,

Ziyun Hu

et al.

Biogerontology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Language: Английский

Citations

0
The role of senescence in cancer therapy-associated cardiovascular toxicity DOI Open Access

Yasmin K. Alshoubaki,

Vivienne Grüterich,

Valentina Zollet

et al.

The Journal of Cardiovascular Aging, Journal Year: 2024, Volume and Issue: 4(4)

Published: Nov. 19, 2024

Cardiovascular diseases (CVDs) and cancer are the two leading causes of global mortality. Cancer treatments, including radiotherapy chemotherapy, can have severe cardiotoxic side effects, raising concerns for patients increasing financial burden on healthcare systems. Recent studies shown a link between therapy-induced cardiotoxicity cardiac senescence. Specifically, systemic therapies known to induce senescence, which may directly result in dysfunction or enhance vulnerability heart other stressors. Besides anthracyclines, newer, more targeted such as tyrosine kinase inhibitors (TKIs) also been Cellular senescence is triggered by DNA damage, oncogene activation, reactive oxygen nitrogen species, stressors, secretion proinflammatory factors, increased oxidative stress, disruption normal cellular functions. Understanding molecular mechanisms induced therapy essential attenuating even preventing clinically overt using senotherapies senolytics senomorphics. In this review, that associated with CVDs described an emphasis potential role disease progression. addition, particularly doxorubicin (DOX), radiotherapy, TKIs lead highlighted. Finally, recent novel treating discussed focus targeting following treatment. The field remains its early stages, further research required clarify how treatments contribute cardiotoxicity. At same time, identifying be safely combined drugs protecting health patients.

Language: Английский

Citations

0
Platelet amino acid spectrum and gut microbiota, their links in patients with coronary artery disease and atrial fibrillation DOI Creative Commons

I.O. Melnychuk,

M.L. Sharayeva,

V.N. Kramarova

et al.

GASTROENTEROLOGY, Journal Year: 2023, Volume and Issue: 57(4), P. 227 - 233

Published: Dec. 22, 2023

Background. The aim of our work was to identify the links between platelet amino acid (AA) spectrum and gut microbiota composition in patients with coronary artery disease (CAD) atrial fibrillation (AF) evaluate them. Materials methods. Three hundred were enrolled study. They divided into 3 groups: I — 149 CAD but without arrhythmias, II (CAD + AF) 124 people AF paroxysm, control group (CG) 27 individuals arrhythmias. Platelet AA level assessed by method ion-exchange liquid column chromatography. Gut studied 16-S rRNA sequencing. Results. A significant increase isoleucine (10.73 %), leucine (12.63 %) a decrease threonine (23.05 serine (5.06 glycine (32.21 valine (30.83 platelets levels found (P < 0.05). In addition, they had Bacteroides spp., Faecalibacterium prausnitzii, Actinobacter Streptococcus Ruminococcus spp. Lactobacillus Bifidobacterium Eubacterium rectale glutamine acid, valine, glycine, asparagine highest number correlations species Blautia Akkermansia muciniphila Roseburia inulinivorans acids Conclusions. are closely linked.

Language: Английский

Citations

1